A novel intermittent regimen of norgestimate to preserve the beneficial effects of 17β-estradiol on lipid and lipoprotein profiles

R. A. Lobo, Howard A Zacur, P. Caubel, R. Lane

Research output: Contribution to journalArticle


OBJECTIVE: This study was undertaken to evaluate the effects of 3 dosage levels of intermittent norgestimate plus a constant dose of 17β-estradiol on blood lipid and lipoprotein concentrations in 236 postmenopausal women. STUDY DESIGN: In this multicenter, double-blind, parallel-group trial the subjects were randomly assigned to receive 1 mg estradiol daily or 1 mg estradiol daily plus intermittent (3 days off and 3 days on) doses of 30 μg, 90 μag, or 180 μag norgestimate for 360 days. RESULTS: The regimens of 1 mg estradiol plus 30 μg norgestimate and 1 mg estradiol plus 90 μg norgestimate increased concentrations of high-density lipoprotein cholesterol, HDL 2 high-density lipoprotein cholesterol, HDL 3 high-density lipoprotein cholesterol (except the regimen of 1 mg estradiol plus 30 μg norgestimate at 7 months), and apolipoprotein apo A-I. They decreased total cholesterol concentration, low-density lipoprotein cholesterol concentration, low-density lipoprotein/high-density lipoprotein ratio, apolipoprotein apo B concentration, and Lp(a) lipoprotein concentration, and they attenuated estradiol-induced increases in triglyceride concentrations. In contrast, the regimen of 1 mg estradiol plus 180 μg norgestimate reduced concentrations of high-density lipoprotein cholesterol, high-density lipoprotein HDL 3 cholesterol, and apolipoprorein apo A-I at 7 months and increased the low- density lipoprotein/high-density lipoprotein ratio at 7 months. CONCLUSIONS: An intermittent regimen of norgestimate at 30 or 90 μg daily administered for 3 days off followed by 3 days on preserved the beneficial lipid and lipoprotein changes induced by continuous therapy with 1 mg 17β-estradiol daily; however, 180 μg norgestimate did not do so.

Original languageEnglish (US)
Pages (from-to)41-49
Number of pages9
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1 I
Publication statusPublished - 2000



  • 17β-Estradiol
  • Hormone replacement therapy
  • Lipids
  • Lipoproteins
  • Norgestimate

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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