A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord

Vassilis E. Koliatsos, David L. Shelton, William C. Mobley, Donald L. Price

Research output: Contribution to journalArticle

Abstract

During development and following axonal injury in adults, neurons in the anterior horn of the spinal cord express nerve growth factor receptor (NGF-R) messenger ribonucleic acid (mRNA) and protein. To examine whether unlesioned anterior horn neurons show signs of responsiveness to NGF in adult animals, spinal cords from control rats and monkeys, as well as animals that had received NGF intraventricularly, were processed for NGF-R immunocytochemistry using monoclonal and polyclonal antibodies against NGF-R. In all animals, neurons located in central/ventral sectors of lamina IX in lumbar segments of the spinal cord expressed NGF-R-like immunoreactivity; this population of nerve cells appeared to increase in size after treatment with NGF. Our findings suggest that, in adults, a subset of spinal motor neurons may respond to NGF.

Original languageEnglish (US)
Pages (from-to)121-128
Number of pages8
JournalBrain research
Volume541
Issue number1
DOIs
StatePublished - Feb 8 1991

Keywords

  • Monkey
  • Motor neuron disease
  • Rat
  • Regeneration
  • Spinal cord
  • Trophic factor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord'. Together they form a unique fingerprint.

  • Cite this