A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord

Vassilis El Koliatsos, David L. Shelton, William C. Mobley, Donald L. Price

Research output: Contribution to journalArticle

Abstract

During development and following axonal injury in adults, neurons in the anterior horn of the spinal cord express nerve growth factor receptor (NGF-R) messenger ribonucleic acid (mRNA) and protein. To examine whether unlesioned anterior horn neurons show signs of responsiveness to NGF in adult animals, spinal cords from control rats and monkeys, as well as animals that had received NGF intraventricularly, were processed for NGF-R immunocytochemistry using monoclonal and polyclonal antibodies against NGF-R. In all animals, neurons located in central/ventral sectors of lamina IX in lumbar segments of the spinal cord expressed NGF-R-like immunoreactivity; this population of nerve cells appeared to increase in size after treatment with NGF. Our findings suggest that, in adults, a subset of spinal motor neurons may respond to NGF.

Original languageEnglish (US)
Pages (from-to)121-128
Number of pages8
JournalBrain Research
Volume541
Issue number1
DOIs
StatePublished - Feb 8 1991

Fingerprint

Anterior Horn Cells
Nerve Growth Factor Receptor
Nerve Growth Factor
Spinal Cord
Neurons
Motor Neurons
Haplorhini
Immunohistochemistry
Monoclonal Antibodies
RNA
Wounds and Injuries
Population
Proteins

Keywords

  • Monkey
  • Motor neuron disease
  • Rat
  • Regeneration
  • Spinal cord
  • Trophic factor

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord. / Koliatsos, Vassilis El; Shelton, David L.; Mobley, William C.; Price, Donald L.

In: Brain Research, Vol. 541, No. 1, 08.02.1991, p. 121-128.

Research output: Contribution to journalArticle

Koliatsos, Vassilis El ; Shelton, David L. ; Mobley, William C. ; Price, Donald L. / A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord. In: Brain Research. 1991 ; Vol. 541, No. 1. pp. 121-128.
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