To identify the tumor suppressor gene on human chromosome llpl5, we generated mouse microcell hybrids containing small transferable chromosome lip 15 fragments, which we have termed "DNA superfragments". These hybrids will be used to identify which fragments contain a tumor suppressor gene by direct transfer of the fragments to tumor cells via microcell fusion.
- DNA superfragments
- microcell fusion
- tumor suppressor gene
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)