A Novel General Strategy for Cloning Tumor Suppressor Genes Using Radiation-Reduced Chromosomal Superfragments

Minoru Koi; L. A. Johnson; A. P. Feinberg

doi:10.1620/tjem.168.167

A Novel General Strategy for Cloning Tumor Suppressor Genes Using Radiation-Reduced Chromosomal Superfragments

Minoru Koi, L. A. Johnson, A. P. Feinberg

Research output: Contribution to journal › Article › peer-review

Abstract

To identify the tumor suppressor gene on human chromosome llpl5, we generated mouse microcell hybrids containing small transferable chromosome lip 15 fragments, which we have termed "DNA superfragments". These hybrids will be used to identify which fragments contain a tumor suppressor gene by direct transfer of the fragments to tumor cells via microcell fusion.

Original language	English (US)
Pages (from-to)	167-168
Number of pages	2
Journal	Tohoku Journal of Experimental Medicine
Volume	168
Issue number	2
DOIs	https://doi.org/10.1620/tjem.168.167
State	Published - 1992
Externally published	Yes

Keywords

DNA superfragments
microcell fusion
tumor suppressor gene

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1620/tjem.168.167

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Cite this

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