A Novel General Strategy for Cloning Tumor Suppressor Genes Using Radiation-Reduced Chromosomal Superfragments

Minoru Koi; L. A. Johnson; A. P. Feinberg

doi:10.1620/tjem.168.167

A Novel General Strategy for Cloning Tumor Suppressor Genes Using Radiation-Reduced Chromosomal Superfragments

Minoru Koi, L. A. Johnson, A. P. Feinberg

Research output: Contribution to journal › Article › peer-review

Abstract

To identify the tumor suppressor gene on human chromosome llpl5, we generated mouse microcell hybrids containing small transferable chromosome lip 15 fragments, which we have termed "DNA superfragments". These hybrids will be used to identify which fragments contain a tumor suppressor gene by direct transfer of the fragments to tumor cells via microcell fusion.

Original language	English (US)
Pages (from-to)	167-168
Number of pages	2
Journal	Tohoku Journal of Experimental Medicine
Volume	168
Issue number	2
DOIs	https://doi.org/10.1620/tjem.168.167
State	Published - 1992
Externally published	Yes

Keywords

DNA superfragments
microcell fusion
tumor suppressor gene

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1620/tjem.168.167

Cite this

@article{c5caba80457941a9866de41b339b22ec,

title = "A Novel General Strategy for Cloning Tumor Suppressor Genes Using Radiation-Reduced Chromosomal Superfragments",

abstract = "To identify the tumor suppressor gene on human chromosome llpl5, we generated mouse microcell hybrids containing small transferable chromosome lip 15 fragments, which we have termed {"}DNA superfragments{"}. These hybrids will be used to identify which fragments contain a tumor suppressor gene by direct transfer of the fragments to tumor cells via microcell fusion.",

keywords = "DNA superfragments, microcell fusion, tumor suppressor gene",

author = "Minoru Koi and Johnson, {L. A.} and Feinberg, {A. P.}",

year = "1992",

doi = "10.1620/tjem.168.167",

language = "English (US)",

volume = "168",

pages = "167--168",

journal = "Tohoku Journal of Experimental Medicine",

issn = "0040-8727",

publisher = "Tohoku University Medical Press",

number = "2",

}

TY - JOUR

T1 - A Novel General Strategy for Cloning Tumor Suppressor Genes Using Radiation-Reduced Chromosomal Superfragments

AU - Koi, Minoru

AU - Johnson, L. A.

AU - Feinberg, A. P.

PY - 1992

Y1 - 1992

N2 - To identify the tumor suppressor gene on human chromosome llpl5, we generated mouse microcell hybrids containing small transferable chromosome lip 15 fragments, which we have termed "DNA superfragments". These hybrids will be used to identify which fragments contain a tumor suppressor gene by direct transfer of the fragments to tumor cells via microcell fusion.

AB - To identify the tumor suppressor gene on human chromosome llpl5, we generated mouse microcell hybrids containing small transferable chromosome lip 15 fragments, which we have termed "DNA superfragments". These hybrids will be used to identify which fragments contain a tumor suppressor gene by direct transfer of the fragments to tumor cells via microcell fusion.

KW - DNA superfragments

KW - microcell fusion

KW - tumor suppressor gene

UR - http://www.scopus.com/inward/record.url?scp=0026937830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026937830&partnerID=8YFLogxK

U2 - 10.1620/tjem.168.167

DO - 10.1620/tjem.168.167

M3 - Article

C2 - 1306300

AN - SCOPUS:0026937830

VL - 168

SP - 167

EP - 168

JO - Tohoku Journal of Experimental Medicine

JF - Tohoku Journal of Experimental Medicine

SN - 0040-8727

IS - 2

ER -

A Novel General Strategy for Cloning Tumor Suppressor Genes Using Radiation-Reduced Chromosomal Superfragments

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this