A Novel General Strategy for Cloning Tumor Suppressor Genes Using Radiation-Reduced Chromosomal Superfragments

Minoru Koi, L. A. Johnson, A. P. Feinberg

Research output: Contribution to journalArticlepeer-review

Abstract

To identify the tumor suppressor gene on human chromosome llpl5, we generated mouse microcell hybrids containing small transferable chromosome lip 15 fragments, which we have termed "DNA superfragments". These hybrids will be used to identify which fragments contain a tumor suppressor gene by direct transfer of the fragments to tumor cells via microcell fusion.

Original languageEnglish (US)
Pages (from-to)167-168
Number of pages2
JournalTohoku Journal of Experimental Medicine
Volume168
Issue number2
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • DNA superfragments
  • microcell fusion
  • tumor suppressor gene

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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