A novel fucose recognition fold involved in innate immunity

Mario Antonio Bianchet, Eric W. Odom, Gerardo R. Vasta, Mario L Amzel

Research output: Contribution to journalArticle

Abstract

Anguilla anguilla agglutinin (AAA), a fucolectin found in the serum of European eel, participates in the recognition of bacterial liposaccharides by the animal innate immunity system. Because AAA specifically recognizes fucosylated terminals of H and Lewis (a) blood groups, it has been used extensively as a reagent in blood typing and histochemistry. AAA contains a newly discovered carbohydrate recognition domain present in proteins of organisms ranging from bacteria to vertebrates. The crystal structure of the complex of AAA with α-L-fucose characterizes the novel fold of this entire lectin family, identifying the residues that provide the structural determinants of oligosaccharide specificity. Modification of these residues explains how the different isoforms in serum can provide a diverse pathogen-specific recognition.

Original languageEnglish (US)
Pages (from-to)628-634
Number of pages7
JournalNature Structural Biology
Volume9
Issue number8
DOIs
StatePublished - 2002

Fingerprint

Anguilla
Fucose
Agglutinins
Innate Immunity
Pathogens
Blood Group Antigens
Oligosaccharides
Lectins
Bacteria
Protein Isoforms
Animals
Blood
Crystal structure
Carbohydrates
Blood Grouping and Crossmatching
Eels
Serum
Vertebrates
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Structural Biology
  • Genetics

Cite this

A novel fucose recognition fold involved in innate immunity. / Bianchet, Mario Antonio; Odom, Eric W.; Vasta, Gerardo R.; Amzel, Mario L.

In: Nature Structural Biology, Vol. 9, No. 8, 2002, p. 628-634.

Research output: Contribution to journalArticle

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