A novel fucose recognition fold involved in innate immunity

Mario A. Bianchet, Eric W. Odom, Gerardo R. Vasta, L. Mario Amzel

Research output: Contribution to journalArticlepeer-review

Abstract

Anguilla anguilla agglutinin (AAA), a fucolectin found in the serum of European eel, participates in the recognition of bacterial liposaccharides by the animal innate immunity system. Because AAA specifically recognizes fucosylated terminals of H and Lewis (a) blood groups, it has been used extensively as a reagent in blood typing and histochemistry. AAA contains a newly discovered carbohydrate recognition domain present in proteins of organisms ranging from bacteria to vertebrates. The crystal structure of the complex of AAA with α-L-fucose characterizes the novel fold of this entire lectin family, identifying the residues that provide the structural determinants of oligosaccharide specificity. Modification of these residues explains how the different isoforms in serum can provide a diverse pathogen-specific recognition.

Original languageEnglish (US)
Pages (from-to)628-634
Number of pages7
JournalNature structural biology
Volume9
Issue number8
DOIs
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics

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