TY - JOUR
T1 - A novel dual energy method for enhanced quantitative computed tomography
AU - Emami, A.
AU - Ghadiri, H.
AU - Rahmim, A.
AU - Ay, M. R.
N1 - Funding Information:
This work was supported by the Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences and the Iranian Foundation of National Genius (Grant no. 7719).
Publisher Copyright:
© 2018 IOP Publishing Ltd and Sissa Medialab.
PY - 2018/1
Y1 - 2018/1
N2 - Accurate assessment of bone mineral density (BMD) is critically important in clinical practice, and conveniently enabled via quantitative computed tomography (QCT). Meanwhile, dual-energy QCT (DEQCT) enables enhanced detection of small changes in BMD relative to single-energy QCT (SEQCT). In the present study, we aimed to investigate the accuracy of QCT methods, with particular emphasis on a new dual-energy approach, in comparison to single-energy and conventional dual-energy techniques. We used a sinogram-based analytical CT simulator to model the complete chain of CT data acquisitions, and assessed performance of SEQCT and different DEQCT techniques in quantification of BMD. We demonstrate a 120% reduction in error when using a proposed dual-energy Simultaneous Equation by Constrained Least-squares method, enabling more accurate bone mineral measurements.
AB - Accurate assessment of bone mineral density (BMD) is critically important in clinical practice, and conveniently enabled via quantitative computed tomography (QCT). Meanwhile, dual-energy QCT (DEQCT) enables enhanced detection of small changes in BMD relative to single-energy QCT (SEQCT). In the present study, we aimed to investigate the accuracy of QCT methods, with particular emphasis on a new dual-energy approach, in comparison to single-energy and conventional dual-energy techniques. We used a sinogram-based analytical CT simulator to model the complete chain of CT data acquisitions, and assessed performance of SEQCT and different DEQCT techniques in quantification of BMD. We demonstrate a 120% reduction in error when using a proposed dual-energy Simultaneous Equation by Constrained Least-squares method, enabling more accurate bone mineral measurements.
KW - Computerized Tomography (CT) and Computed Radiography (CR)
KW - Software architectures (event data models, frameworks and databases)
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U2 - 10.1088/1748-0221/13/01/P01030
DO - 10.1088/1748-0221/13/01/P01030
M3 - Article
AN - SCOPUS:85041474741
SN - 1748-0221
VL - 13
JO - Journal of Instrumentation
JF - Journal of Instrumentation
IS - 1
M1 - P01030
ER -