A novel dual energy method for enhanced quantitative computed tomography

A. Emami, H. Ghadiri, A. Rahmim, M. R. Ay

Research output: Contribution to journalArticlepeer-review


Accurate assessment of bone mineral density (BMD) is critically important in clinical practice, and conveniently enabled via quantitative computed tomography (QCT). Meanwhile, dual-energy QCT (DEQCT) enables enhanced detection of small changes in BMD relative to single-energy QCT (SEQCT). In the present study, we aimed to investigate the accuracy of QCT methods, with particular emphasis on a new dual-energy approach, in comparison to single-energy and conventional dual-energy techniques. We used a sinogram-based analytical CT simulator to model the complete chain of CT data acquisitions, and assessed performance of SEQCT and different DEQCT techniques in quantification of BMD. We demonstrate a 120% reduction in error when using a proposed dual-energy Simultaneous Equation by Constrained Least-squares method, enabling more accurate bone mineral measurements.

Original languageEnglish (US)
Article numberP01030
JournalJournal of Instrumentation
Issue number1
StatePublished - Jan 2018


  • Computerized Tomography (CT) and Computed Radiography (CR)
  • Software architectures (event data models, frameworks and databases)

ASJC Scopus subject areas

  • Mathematical Physics
  • Instrumentation


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