A novel cardiac potassium channel that is active and conductive at depolarized potentials

David T. Yue, Eduardo Marban

Research output: Contribution to journalArticle

Abstract

We report the existence of a novel potassium channel revealed in single-channel recordings from guinea-pig ventricular heart cells. The channel, observed in ∼10% of patches, demonstrates a 14 pS conductance at physiological potassium concentrations, does not rectify over the voltage range of the action potential, and is quite selective for K ions. The channel activates with depolarization, but does not require intracellular Ca2+ ions to open. Open channel probability increases rapidly (<10 ms) to a plateau in response to depolarizing voltage steps, and demonstrates no detectable inactivation (>600 ms). These features clearly distinguish this channel from other known K channels in cardiac muscle. Because of its high activity at plateau potentials, we propose the name iKp.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalPflügers Archiv European Journal of Physiology
Volume413
Issue number2
DOIs
StatePublished - Dec 1 1988

Keywords

  • Cardiac action potential
  • Guinea pig
  • K channel
  • Patch clamp
  • Single ventricular cell

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

Fingerprint Dive into the research topics of 'A novel cardiac potassium channel that is active and conductive at depolarized potentials'. Together they form a unique fingerprint.

  • Cite this