Abstract
We report the existence of a novel potassium channel revealed in single-channel recordings from guinea-pig ventricular heart cells. The channel, observed in ∼10% of patches, demonstrates a 14 pS conductance at physiological potassium concentrations, does not rectify over the voltage range of the action potential, and is quite selective for K ions. The channel activates with depolarization, but does not require intracellular Ca2+ ions to open. Open channel probability increases rapidly (<10 ms) to a plateau in response to depolarizing voltage steps, and demonstrates no detectable inactivation (>600 ms). These features clearly distinguish this channel from other known K channels in cardiac muscle. Because of its high activity at plateau potentials, we propose the name iKp.
Original language | English (US) |
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Pages (from-to) | 127-133 |
Number of pages | 7 |
Journal | Pflügers Archiv European Journal of Physiology |
Volume | 413 |
Issue number | 2 |
DOIs | |
State | Published - Dec 1988 |
Keywords
- Cardiac action potential
- Guinea pig
- K channel
- Patch clamp
- Single ventricular cell
ASJC Scopus subject areas
- Physiology
- Clinical Biochemistry
- Physiology (medical)