A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes specific for an MBP epitope unique to myelination

Rhonda R. Voskuhl, Dale E. McFarlin, Laura R. Tranquill, Gladys Deibler, Roger Stone, Heidi Maloni, Henry F. McFarland

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Although the major isoform of myelin basic protein (MBP) in the healthy adult CNS is the 18.5-kDa protein, other isoforms containing exon 2 encoded protein (21.5 kDa and 20.2 kDa) exist and are expressed primarily during myelin formation. Since remyelination is a prominent feature in MS lesions, we examined the frequencies of T cell lines (TCLs) specific for epitopes within exon 2 encoded MBP (X2MBP), and also within 18.5-kDa MBP, in members of a multiplex family with MS. TCLs specific for X2MBP were as prevalent as TCLs specific for immunodominant epitopes within 18.5-kDa MBP. In addition, while frequencies of TCLs specific for 18.5-kDa MBP were no different between the affected and unaffected, the frequency of X2MBP-specific TCLs correlated with disease.

Original languageEnglish (US)
Pages (from-to)137-144
Number of pages8
JournalJournal of Neuroimmunology
Volume46
Issue number1-2
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • Multiple sclerosis
  • Myelin basic protein
  • T lymphocyte

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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