A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project

Latarsha J. Carithers, Kristin Ardlie, Mary Barcus, Philip A. Branton, Angela Britton, Stephen A. Buia, Carolyn C. Compton, David S. Deluca, Joanne Peter-Demchok, Ellen T. Gelfand, Ping Guan, Greg E. Korzeniewski, Nicole C. Lockhart, Chana A. Rabiner, Abhi K. Rao, Karna L. Robinson, Nancy V. Roche, Sherilyn J. Sawyer, Ayellet V. Segrè, Charles E. ShiveAnna M. Smith, Leslie H. Sobin, Anita H. Undale, Kimberly M. Valentino, Jim Vaught, Taylor R. Young, Helen M. Moore, Laura Barker, Margaret Basile, Alexis Battle, Joy Boyer, Debra Bradbury, Jason P. Bridge, Amanda Brown, Robin Burges, Christopher Choi, Deborah Colantuoni, Nancy Cox, Emmanouil T. Dermitzakis, Leslie K. Derr, Michael J. Dinsmore, Kenyon Erickson, Johnelle Fleming, Timothée Flutre, Barbara A. Foster, Eric R. Gamazon, Gad Getz, Bryan M. Gillard, Roderic Guigó, Kenneth W. Hambright, Pushpa Hariharan, Rick Hasz, Hae K. Im, Scott Jewell, Ellen Karasik, Manolis Kellis, Pouya Kheradpour, Susan Koester, Daphne Koller, Anuar Konkashbaev, Tuuli Lappalainen, Roger Little, Jun Liu, Edmund Lo, John T. Lonsdale, Chunrong Lu, Daniel G. MacArthur, Harold Magazine, Julian B. Maller, Yvonne Marcus, Deborah C. Mash, Mark I. McCarthy, Jeffrey McLean, Bernadette Mestichelli, Mark Miklos, Jean Monlong, Magboeba Mosavel, Michael T. Moser, Sara Mostafavi, Dan L. Nicolae, Jonathan Pritchard, Liqun Qi, Kimberly Ramsey, Manuel A. Rivas, Barnaby E. Robles, Daniel C. Rohrer, Mike Salvatore, Michael Sammeth, John Seleski, Saboor Shad, Laura A. Siminoff, Matthew Stephens, Jeff Struewing, Timothy Sullivan, Susan Sullivan, John Syron, David Tabor, Mehran Taherian, Jorge Tejada, Gary F. Temple, Jeffrey A. Thomas, Alexander W. Thomson, Denee Tidwell, Heather M. Traino, Zhidong Tu, Dana R. Valley, Simona Volpi, Gary D. Walters, Lucas D. Ward, Xiaoquan Wen, Wendy Winckler, Shenpei Wu, Jun Zhu, Assya Abdallah, Anjene Addington, James M. Anderson, Patrick K. Bender, Mark Cosentino, Norma Diaz-Mayoral, Theresa Engel, Fernando Garci, Allen Green, Tiffanie Hammond, Katherine Jaffe, Judy Keen, Mary Kennedy, Peter Kigonya, Brent Lander, Sreenath Nampally, Cathy Ny, James Robb, Vikram Santhanum, Nataliya Sharopova, Shilpi Singh, Conrado Soria, Anne Sturcke, Surendra Sukari, Elizabeth J. Thomson, Magda Tomaszewski, Casandra Trowbridge, Ferdinand Udoye, David Vanscoy, Negin Vatanian, Elizabeth L. Wilder, Penelope Williams

Research output: Contribution to journalArticle

Abstract

The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund, was established to study the correlation between human genetic variation and tissue-specific gene expression in non-diseased individuals. A significant challenge was the collection of high-quality biospecimens for extensive genomic analyses. Here we describe how a successful infrastructure for biospecimen procurement was developed and implemented by multiple research partners to support the prospective collection, annotation, and distribution of blood, tissues, and cell lines for the GTEx project. Other research projects can follow this model and form beneficial partnerships with rapid autopsy and organ procurement organizations to collect high quality biospecimens and associated clinical data for genomic studies. Biospecimens, clinical and genomic data, and Standard Operating Procedures guiding biospecimen collection for the GTEx project are available to the research community.

Original languageEnglish (US)
Pages (from-to)311-317
Number of pages7
JournalBiopreservation and Biobanking
Volume13
Issue number5
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

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    Carithers, L. J., Ardlie, K., Barcus, M., Branton, P. A., Britton, A., Buia, S. A., Compton, C. C., Deluca, D. S., Peter-Demchok, J., Gelfand, E. T., Guan, P., Korzeniewski, G. E., Lockhart, N. C., Rabiner, C. A., Rao, A. K., Robinson, K. L., Roche, N. V., Sawyer, S. J., Segrè, A. V., ... Williams, P. (2015). A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project. Biopreservation and Biobanking, 13(5), 311-317. https://doi.org/10.1089/bio.2015.0032