A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

Swapan K. Nath, Shizhong Han, Xana Kim-Howard, Jennifer A. Kelly, Parvathi Viswanathan, Gary S. Gilkeson, Wei Chen, Cheng Zhu, Rodger P. McEver, Robert P. Kimberly, Marta E. Alarcón-Riquelme, Timothy J. Vyse, Quan Zhen Li, Edward K. Wakeland, Joan T. Merrill, Judith A. James, Kenneth M. Kaufman, Joel M. Guthridge, John B. Harley

Research output: Contribution to journalArticlepeer-review


We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P = 1.7 × 10-17, odds ratio = 1.78). We further replicated this association in two independent samples of individuals of African descent (P = 0.0002 and 0.003; overall meta-analysis P = 6.9 × 10 -22). The genetic association between ITGAM and SLE implicates the αMβ2-integrin adhesion pathway in disease development.

Original languageEnglish (US)
Pages (from-to)152-154
Number of pages3
JournalNature genetics
Issue number2
StatePublished - Feb 2008
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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