A non-cytotoxic suppressor of immunoglobulin synthesis and secretion by b cells of normal humans and patients with rheumatoid arthritis and systemic lupus erythematosus

Maxwell Richter, Harvey Kaplan, Gunnar Kraag, Eyal Talor, Carol Ann Jodouin

Research output: Contribution to journalArticlepeer-review

Abstract

A factor secrected by thymocytes of immunized rabbits totally suppressed both the initiation of, and ongoing synthesis and secretion of, lectin (PWM)-induced synthesis of IgM and IgG immunoglobulins by the circulating B lymphocytes of normal humans, and of twenty consecutive patients with rheumatoid arthritis and twelve consecutive patients with systemic lupus erythematosus. The suppressor factor, referred to as human Ig synthesis/secretion suppressor factor or HISSF, is not HLA restricted in its activity and is not cytotoxic to the circulating human mononuclear cells (B cells, T cells. Null cells and monocytes). It was demonstrated that T cells precultured with HISSF were transformed into suppressor cells which, when added to fresh cultures of autologous B cells, suppressed the synthesis and secretion of IgM and IgG. On the basis of its suppressive and non-cytotoxic properties in vitro, HISSF may be an effective immunosuppressant in the treatment of patients with autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)107-117
Number of pages11
JournalAutoimmunity
Volume11
Issue number2
DOIs
StatePublished - 1991

Keywords

  • Human
  • Non-toxic suppressor factor
  • Suppression of autoantibody synthesis
  • Suppression of immunoglobulin synthesis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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