A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices

Genki Minamisawa, Sung Eun Kwon, Maxime Chevée, Solange P Brown, Daniel H O'Connor

Research output: Contribution to journalArticle

Abstract

Sensory perception depends on interactions among cortical areas. These interactions are mediated by canonical patterns of connectivity in which higher areas send feedback projections to lower areas via neurons in superficial and deep layers. Here, we probed the circuit basis of interactions among two areas critical for touch perception in mice, whisker primary (wS1) and secondary (wS2) somatosensory cortices. Neurons in layer 4 of wS2 (S2L4) formed a major feedback pathway to wS1. Feedback from wS2 to wS1 was organized somatotopically. Spikes evoked by whisker deflections occurred nearly as rapidly in wS2 as in wS1, including among putative S2L4 → S1 feedback neurons. Axons from S2L4 → S1 neurons sent stimulus orientation-specific activity to wS1. Optogenetic excitation of S2L4 neurons modulated activity across both wS2 and wS1, while inhibition of S2L4 reduced orientation tuning among wS1 neurons. Thus, a non-canonical feedback circuit, originating in layer 4 of S2, rapidly modulates early tactile processing. Minamisawa et al. uncover a rapid feedback pathway between secondary and primary somatosensory cortices that arises from layer 4 and acts to enhance sensory feature representation.

Original languageEnglish (US)
Pages (from-to)2718-2731.e6
JournalCell Reports
Volume23
Issue number9
DOIs
StatePublished - May 29 2018

Fingerprint

Somatosensory Cortex
Neurons
Feedback
Networks (circuits)
Vibrissae
Touch Perception
Optogenetics
Touch
Axons
Tuning
Processing

Keywords

  • barrel cortex
  • feedback
  • layer 4
  • optogenetics
  • orientation selectivity
  • projection-specific
  • S1
  • S2
  • secondary somatosensory cortex
  • whisker system

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices. / Minamisawa, Genki; Kwon, Sung Eun; Chevée, Maxime; Brown, Solange P; O'Connor, Daniel H.

In: Cell Reports, Vol. 23, No. 9, 29.05.2018, p. 2718-2731.e6.

Research output: Contribution to journalArticle

Minamisawa, Genki ; Kwon, Sung Eun ; Chevée, Maxime ; Brown, Solange P ; O'Connor, Daniel H. / A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices. In: Cell Reports. 2018 ; Vol. 23, No. 9. pp. 2718-2731.e6.
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