A nomogram to predict long-term survival after resection for intrahepatic cholangiocarcinoma: An Eastern and Western experience

Omar Hyder, Hugo Marques, Carlo Pulitano, J. Wallis Marsh, Sorin Alexandrescu, Todd W. Bauer, T. Clark Gamblin, Georgios C. Sotiropoulos, Andreas Paul, Eduardo Barroso, Bryan M. Clary, Luca Aldrighetti, Cristina R. Ferrone, Andrew X. Zhu, Irinel Popescu, Jean Francois Gigot, Gilles Mentha, Shen Feng, Timothy M. Pawlik

Research output: Contribution to journalArticlepeer-review

Abstract

IMPORTANCE Intrahepatic cholangiocarcinoma (ICC) is a primary cancer of the liver that is increasing in incidence, and the prognostic factors associated with outcome after surgery remain poorly defined. OBJECTIVE To combine clinicopathologic variables associated with overall survival after resection of ICC into a prediction nomogram. DESIGN, SETTING, AND PARTICIPANTS We performed an international multicenter study of 514 patients who underwent resection for ICC at 13 major hepatobiliary centers in the United States, Europe, and Asia from May 1, 1990, through December 31, 2011. Multivariate Cox proportional hazards regression modeling with backward selection using the Akaike information criteria was used to select variables for construction of the nomogram. Discrimination and calibration were performed using Kaplan-Meier curves and calibration plots. INTERVENTIONS Surgical resection of ICC at a participating hospital. MAIN OUTCOMES AND MEASURES Long-term survival, effect of potential prognostic factors, and performance of proposed nomogram. RESULTS Median patient age was 59.2 years, and 53.1%of the patients were male. Most patients (74.7%) had a solitary tumor, and median tumor size was 6.0 cm. Patients were treated with an extended hepatectomy (202 [39.3%]), a hemihepatectomy (180 [35.0%]), or a minor liver resection (

Original languageEnglish (US)
Pages (from-to)432-438
Number of pages7
JournalJAMA Surgery
Volume149
Issue number5
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Surgery

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