TY - JOUR
T1 - A nomogram to predict long-term survival after resection for intrahepatic cholangiocarcinoma
T2 - An Eastern and Western experience
AU - Hyder, Omar
AU - Marques, Hugo
AU - Pulitano, Carlo
AU - Marsh, J. Wallis
AU - Alexandrescu, Sorin
AU - Bauer, Todd W.
AU - Gamblin, T. Clark
AU - Sotiropoulos, Georgios C.
AU - Paul, Andreas
AU - Barroso, Eduardo
AU - Clary, Bryan M.
AU - Aldrighetti, Luca
AU - Ferrone, Cristina R.
AU - Zhu, Andrew X.
AU - Popescu, Irinel
AU - Gigot, Jean Francois
AU - Mentha, Gilles
AU - Feng, Shen
AU - Pawlik, Timothy M.
PY - 2014
Y1 - 2014
N2 - IMPORTANCE Intrahepatic cholangiocarcinoma (ICC) is a primary cancer of the liver that is increasing in incidence, and the prognostic factors associated with outcome after surgery remain poorly defined. OBJECTIVE To combine clinicopathologic variables associated with overall survival after resection of ICC into a prediction nomogram. DESIGN, SETTING, AND PARTICIPANTS We performed an international multicenter study of 514 patients who underwent resection for ICC at 13 major hepatobiliary centers in the United States, Europe, and Asia from May 1, 1990, through December 31, 2011. Multivariate Cox proportional hazards regression modeling with backward selection using the Akaike information criteria was used to select variables for construction of the nomogram. Discrimination and calibration were performed using Kaplan-Meier curves and calibration plots. INTERVENTIONS Surgical resection of ICC at a participating hospital. MAIN OUTCOMES AND MEASURES Long-term survival, effect of potential prognostic factors, and performance of proposed nomogram. RESULTS Median patient age was 59.2 years, and 53.1%of the patients were male. Most patients (74.7%) had a solitary tumor, and median tumor size was 6.0 cm. Patients were treated with an extended hepatectomy (202 [39.3%]), a hemihepatectomy (180 [35.0%]), or a minor liver resection (
AB - IMPORTANCE Intrahepatic cholangiocarcinoma (ICC) is a primary cancer of the liver that is increasing in incidence, and the prognostic factors associated with outcome after surgery remain poorly defined. OBJECTIVE To combine clinicopathologic variables associated with overall survival after resection of ICC into a prediction nomogram. DESIGN, SETTING, AND PARTICIPANTS We performed an international multicenter study of 514 patients who underwent resection for ICC at 13 major hepatobiliary centers in the United States, Europe, and Asia from May 1, 1990, through December 31, 2011. Multivariate Cox proportional hazards regression modeling with backward selection using the Akaike information criteria was used to select variables for construction of the nomogram. Discrimination and calibration were performed using Kaplan-Meier curves and calibration plots. INTERVENTIONS Surgical resection of ICC at a participating hospital. MAIN OUTCOMES AND MEASURES Long-term survival, effect of potential prognostic factors, and performance of proposed nomogram. RESULTS Median patient age was 59.2 years, and 53.1%of the patients were male. Most patients (74.7%) had a solitary tumor, and median tumor size was 6.0 cm. Patients were treated with an extended hepatectomy (202 [39.3%]), a hemihepatectomy (180 [35.0%]), or a minor liver resection (
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U2 - 10.1001/jamasurg.2013.5168
DO - 10.1001/jamasurg.2013.5168
M3 - Article
C2 - 24599477
AN - SCOPUS:84901307929
SN - 2168-6254
VL - 149
SP - 432
EP - 438
JO - JAMA Surgery
JF - JAMA Surgery
IS - 5
ER -