A niche for infectious disease in environmental health: Rethinking the toxicological paradigm

Beth J. Feingold, Leora Vegosen, Meghan Davis, Jessica Leibler, Amy Peterson, Ellen Silbergeld

Research output: Contribution to journalArticle

Abstract

Objective: In this review we highlight the need to expand the scope of environmental health research, which now focuses largely on the study of toxicants, to incorporate infectious agents. We provide evidence that environmental health research would be strengthened through finding common ground with the tools and approaches of infectious disease research. Data sources and extraction: We conducted a literature review for examples of interactions between toxic agents and infectious diseases, as well as the role of these interactions as risk factors in classic "environmental" diseases. We investigated existing funding sources and research mandates in the United States from the National Science Foundation and the National Institutes of Health, particularly the National Institute of Environmental Health Sciences. Data synthesis: We adapted the toxicological paradigm to guide reintegration of infectious disease into environmental health research and to identify common ground between these two fields as well as opportunities for improving public health through interdisciplinary research. Conclusions: Environmental health encompasses complex disease processes, many of which involve interactions among multiple risk factors, including toxicant exposures, pathogens, and susceptibility. Funding and program mandates for environmental health studies should be expanded to include pathogens in order to capture the true scope of these overlapping risks, thus creating more effective research investments with greater relevance to the complexity of real-world exposures and multifactorial health outcomes. We propose a new model that integrates the toxicology and infectious disease paradigms to facilitate improved collaboration and communication by providing a framework for interdisciplinary research. Pathogens should be part of environmental health research planning and funding allocation, as well as applications such as surveillance and policy development.

Original languageEnglish (US)
Pages (from-to)1165-1172
Number of pages8
JournalEnvironmental Health Perspectives
Volume118
Issue number8
DOIs
StatePublished - 2010

Fingerprint

Environmental Health
Toxicology
Communicable Diseases
Research
National Institute of Environmental Health Sciences (U.S.)
Health Planning
Policy Making
Poisons
Information Storage and Retrieval
National Institutes of Health (U.S.)
Public Health
Health

Keywords

  • Biomarkers
  • Colon cancer
  • Conceptual framework
  • Environmental health
  • Infectious disease
  • Liver cancer
  • Niehs
  • Pathogens
  • Toxicology

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health

Cite this

A niche for infectious disease in environmental health : Rethinking the toxicological paradigm. / Feingold, Beth J.; Vegosen, Leora; Davis, Meghan; Leibler, Jessica; Peterson, Amy; Silbergeld, Ellen.

In: Environmental Health Perspectives, Vol. 118, No. 8, 2010, p. 1165-1172.

Research output: Contribution to journalArticle

Feingold, Beth J. ; Vegosen, Leora ; Davis, Meghan ; Leibler, Jessica ; Peterson, Amy ; Silbergeld, Ellen. / A niche for infectious disease in environmental health : Rethinking the toxicological paradigm. In: Environmental Health Perspectives. 2010 ; Vol. 118, No. 8. pp. 1165-1172.
@article{a5a3dab45ed94318b1e84d5eed8611b4,
title = "A niche for infectious disease in environmental health: Rethinking the toxicological paradigm",
abstract = "Objective: In this review we highlight the need to expand the scope of environmental health research, which now focuses largely on the study of toxicants, to incorporate infectious agents. We provide evidence that environmental health research would be strengthened through finding common ground with the tools and approaches of infectious disease research. Data sources and extraction: We conducted a literature review for examples of interactions between toxic agents and infectious diseases, as well as the role of these interactions as risk factors in classic {"}environmental{"} diseases. We investigated existing funding sources and research mandates in the United States from the National Science Foundation and the National Institutes of Health, particularly the National Institute of Environmental Health Sciences. Data synthesis: We adapted the toxicological paradigm to guide reintegration of infectious disease into environmental health research and to identify common ground between these two fields as well as opportunities for improving public health through interdisciplinary research. Conclusions: Environmental health encompasses complex disease processes, many of which involve interactions among multiple risk factors, including toxicant exposures, pathogens, and susceptibility. Funding and program mandates for environmental health studies should be expanded to include pathogens in order to capture the true scope of these overlapping risks, thus creating more effective research investments with greater relevance to the complexity of real-world exposures and multifactorial health outcomes. We propose a new model that integrates the toxicology and infectious disease paradigms to facilitate improved collaboration and communication by providing a framework for interdisciplinary research. Pathogens should be part of environmental health research planning and funding allocation, as well as applications such as surveillance and policy development.",
keywords = "Biomarkers, Colon cancer, Conceptual framework, Environmental health, Infectious disease, Liver cancer, Niehs, Pathogens, Toxicology",
author = "Feingold, {Beth J.} and Leora Vegosen and Meghan Davis and Jessica Leibler and Amy Peterson and Ellen Silbergeld",
year = "2010",
doi = "10.1289/ehp.0901866",
language = "English (US)",
volume = "118",
pages = "1165--1172",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "Public Health Services, US Dept of Health and Human Services",
number = "8",

}

TY - JOUR

T1 - A niche for infectious disease in environmental health

T2 - Rethinking the toxicological paradigm

AU - Feingold, Beth J.

AU - Vegosen, Leora

AU - Davis, Meghan

AU - Leibler, Jessica

AU - Peterson, Amy

AU - Silbergeld, Ellen

PY - 2010

Y1 - 2010

N2 - Objective: In this review we highlight the need to expand the scope of environmental health research, which now focuses largely on the study of toxicants, to incorporate infectious agents. We provide evidence that environmental health research would be strengthened through finding common ground with the tools and approaches of infectious disease research. Data sources and extraction: We conducted a literature review for examples of interactions between toxic agents and infectious diseases, as well as the role of these interactions as risk factors in classic "environmental" diseases. We investigated existing funding sources and research mandates in the United States from the National Science Foundation and the National Institutes of Health, particularly the National Institute of Environmental Health Sciences. Data synthesis: We adapted the toxicological paradigm to guide reintegration of infectious disease into environmental health research and to identify common ground between these two fields as well as opportunities for improving public health through interdisciplinary research. Conclusions: Environmental health encompasses complex disease processes, many of which involve interactions among multiple risk factors, including toxicant exposures, pathogens, and susceptibility. Funding and program mandates for environmental health studies should be expanded to include pathogens in order to capture the true scope of these overlapping risks, thus creating more effective research investments with greater relevance to the complexity of real-world exposures and multifactorial health outcomes. We propose a new model that integrates the toxicology and infectious disease paradigms to facilitate improved collaboration and communication by providing a framework for interdisciplinary research. Pathogens should be part of environmental health research planning and funding allocation, as well as applications such as surveillance and policy development.

AB - Objective: In this review we highlight the need to expand the scope of environmental health research, which now focuses largely on the study of toxicants, to incorporate infectious agents. We provide evidence that environmental health research would be strengthened through finding common ground with the tools and approaches of infectious disease research. Data sources and extraction: We conducted a literature review for examples of interactions between toxic agents and infectious diseases, as well as the role of these interactions as risk factors in classic "environmental" diseases. We investigated existing funding sources and research mandates in the United States from the National Science Foundation and the National Institutes of Health, particularly the National Institute of Environmental Health Sciences. Data synthesis: We adapted the toxicological paradigm to guide reintegration of infectious disease into environmental health research and to identify common ground between these two fields as well as opportunities for improving public health through interdisciplinary research. Conclusions: Environmental health encompasses complex disease processes, many of which involve interactions among multiple risk factors, including toxicant exposures, pathogens, and susceptibility. Funding and program mandates for environmental health studies should be expanded to include pathogens in order to capture the true scope of these overlapping risks, thus creating more effective research investments with greater relevance to the complexity of real-world exposures and multifactorial health outcomes. We propose a new model that integrates the toxicology and infectious disease paradigms to facilitate improved collaboration and communication by providing a framework for interdisciplinary research. Pathogens should be part of environmental health research planning and funding allocation, as well as applications such as surveillance and policy development.

KW - Biomarkers

KW - Colon cancer

KW - Conceptual framework

KW - Environmental health

KW - Infectious disease

KW - Liver cancer

KW - Niehs

KW - Pathogens

KW - Toxicology

UR - http://www.scopus.com/inward/record.url?scp=77956074266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956074266&partnerID=8YFLogxK

U2 - 10.1289/ehp.0901866

DO - 10.1289/ehp.0901866

M3 - Article

C2 - 20385515

AN - SCOPUS:77956074266

VL - 118

SP - 1165

EP - 1172

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 8

ER -