A new version of the thalamic disinhibition hypothesis of central pain

A. D. Craig, D. Bowsher, R. R. Tasker, F. A. Lenz, P. M. Dougherty, Z. Wiesenfeld- Hallin

Research output: Contribution to journalReview article

Abstract

The hypothesis is presented that central pain is due to the disruption of thermosensory integration and the loss of cold inhibition of burning pain. This is a new variation on the thalamic disinhibition hypothesis originally proposed by H. Head and G. Holmes in 1911 (Brain 34:102-254). The thermal grill illusion of pain provides a model for this concept. Functional anatomic substrates are described that provide a sound framework for the hypothesis. Predictions are made and unresolved issues are addressed that provide opportunities to test this hypothesis.

Original languageEnglish (US)
Pages (from-to)1-28
Number of pages28
JournalPain Forum
Volume7
Issue number1
StatePublished - Jan 1 1998
Externally publishedYes

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Keywords

  • Cingulate
  • Insula
  • Pain
  • Thalamus
  • Thermoreception

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Craig, A. D., Bowsher, D., Tasker, R. R., Lenz, F. A., Dougherty, P. M., & Wiesenfeld- Hallin, Z. (1998). A new version of the thalamic disinhibition hypothesis of central pain. Pain Forum, 7(1), 1-28.