A new version of the thalamic disinhibition hypothesis of central pain

A. D. Craig, D. Bowsher, R. R. Tasker, Frederick Lenz, P. M. Dougherty, Z. Wiesenfeld- Hallin

Research output: Contribution to journalArticle

Abstract

The hypothesis is presented that central pain is due to the disruption of thermosensory integration and the loss of cold inhibition of burning pain. This is a new variation on the thalamic disinhibition hypothesis originally proposed by H. Head and G. Holmes in 1911 (Brain 34:102-254). The thermal grill illusion of pain provides a model for this concept. Functional anatomic substrates are described that provide a sound framework for the hypothesis. Predictions are made and unresolved issues are addressed that provide opportunities to test this hypothesis.

Original languageEnglish (US)
Pages (from-to)1-28
Number of pages28
JournalPain Forum
Volume7
Issue number1
StatePublished - 1998
Externally publishedYes

Fingerprint

Pain
Hot Temperature
Brain
Inhibition (Psychology)

Keywords

  • Cingulate
  • Insula
  • Pain
  • Thalamus
  • Thermoreception

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Craig, A. D., Bowsher, D., Tasker, R. R., Lenz, F., Dougherty, P. M., & Wiesenfeld- Hallin, Z. (1998). A new version of the thalamic disinhibition hypothesis of central pain. Pain Forum, 7(1), 1-28.

A new version of the thalamic disinhibition hypothesis of central pain. / Craig, A. D.; Bowsher, D.; Tasker, R. R.; Lenz, Frederick; Dougherty, P. M.; Wiesenfeld- Hallin, Z.

In: Pain Forum, Vol. 7, No. 1, 1998, p. 1-28.

Research output: Contribution to journalArticle

Craig, AD, Bowsher, D, Tasker, RR, Lenz, F, Dougherty, PM & Wiesenfeld- Hallin, Z 1998, 'A new version of the thalamic disinhibition hypothesis of central pain', Pain Forum, vol. 7, no. 1, pp. 1-28.
Craig AD, Bowsher D, Tasker RR, Lenz F, Dougherty PM, Wiesenfeld- Hallin Z. A new version of the thalamic disinhibition hypothesis of central pain. Pain Forum. 1998;7(1):1-28.
Craig, A. D. ; Bowsher, D. ; Tasker, R. R. ; Lenz, Frederick ; Dougherty, P. M. ; Wiesenfeld- Hallin, Z. / A new version of the thalamic disinhibition hypothesis of central pain. In: Pain Forum. 1998 ; Vol. 7, No. 1. pp. 1-28.
@article{a01c8c2d110d4aefac43b456252375df,
title = "A new version of the thalamic disinhibition hypothesis of central pain",
abstract = "The hypothesis is presented that central pain is due to the disruption of thermosensory integration and the loss of cold inhibition of burning pain. This is a new variation on the thalamic disinhibition hypothesis originally proposed by H. Head and G. Holmes in 1911 (Brain 34:102-254). The thermal grill illusion of pain provides a model for this concept. Functional anatomic substrates are described that provide a sound framework for the hypothesis. Predictions are made and unresolved issues are addressed that provide opportunities to test this hypothesis.",
keywords = "Cingulate, Insula, Pain, Thalamus, Thermoreception",
author = "Craig, {A. D.} and D. Bowsher and Tasker, {R. R.} and Frederick Lenz and Dougherty, {P. M.} and {Wiesenfeld- Hallin}, Z.",
year = "1998",
language = "English (US)",
volume = "7",
pages = "1--28",
journal = "Journal of Pain",
issn = "1526-5900",
publisher = "Churchill Livingstone",
number = "1",

}

TY - JOUR

T1 - A new version of the thalamic disinhibition hypothesis of central pain

AU - Craig, A. D.

AU - Bowsher, D.

AU - Tasker, R. R.

AU - Lenz, Frederick

AU - Dougherty, P. M.

AU - Wiesenfeld- Hallin, Z.

PY - 1998

Y1 - 1998

N2 - The hypothesis is presented that central pain is due to the disruption of thermosensory integration and the loss of cold inhibition of burning pain. This is a new variation on the thalamic disinhibition hypothesis originally proposed by H. Head and G. Holmes in 1911 (Brain 34:102-254). The thermal grill illusion of pain provides a model for this concept. Functional anatomic substrates are described that provide a sound framework for the hypothesis. Predictions are made and unresolved issues are addressed that provide opportunities to test this hypothesis.

AB - The hypothesis is presented that central pain is due to the disruption of thermosensory integration and the loss of cold inhibition of burning pain. This is a new variation on the thalamic disinhibition hypothesis originally proposed by H. Head and G. Holmes in 1911 (Brain 34:102-254). The thermal grill illusion of pain provides a model for this concept. Functional anatomic substrates are described that provide a sound framework for the hypothesis. Predictions are made and unresolved issues are addressed that provide opportunities to test this hypothesis.

KW - Cingulate

KW - Insula

KW - Pain

KW - Thalamus

KW - Thermoreception

UR - http://www.scopus.com/inward/record.url?scp=0031967098&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031967098&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0031967098

VL - 7

SP - 1

EP - 28

JO - Journal of Pain

JF - Journal of Pain

SN - 1526-5900

IS - 1

ER -