The hypothesis is presented that central pain is due to the disruption of thermosensory integration and the loss of cold inhibition of burning pain. This is a new variation on the thalamic disinhibition hypothesis originally proposed by H. Head and G. Holmes in 1911 (Brain 34:102-254). The thermal grill illusion of pain provides a model for this concept. Functional anatomic substrates are described that provide a sound framework for the hypothesis. Predictions are made and unresolved issues are addressed that provide opportunities to test this hypothesis.
|Original language||English (US)|
|Number of pages||28|
|State||Published - 1998|
ASJC Scopus subject areas
- Clinical Neurology
- Anesthesiology and Pain Medicine