TY - JOUR
T1 - A new technique with high reproducibility to estimate renal oxygenation using BOLD-MRI in chronic kidney disease
AU - Piskunowicz, Maciej
AU - Hofmann, Lucie
AU - Zuercher, Emilie
AU - Bassi, Isabelle
AU - Milani, Bastien
AU - Stuber, Matthias
AU - Narkiewicz, Krzysztof
AU - Vogt, Bruno
AU - Burnier, Michel
AU - Pruijm, Menno
N1 - Funding Information:
This study was supported by a grant from the Swiss National Science Foundation ( FN 32003B-149309 ). Maciej Piskunowicz is supported by a research fellowship from the Scientific Exchange Program — Sciex-NMS ch .
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Objectives: To assess inter-observer variability of renal blood oxygenation level-dependent MRI (BOLD-MRI) using a new method of analysis, called the concentric objects (CO) technique, in comparison with the classical ROI (region of interest)-based technique. Methods: MR imaging (3T) was performed before and after furosemide in 10 chronic kidney disease (CKD) patients (mean eGFR 43±24ml/min/1.73m2) and 10 healthy volunteers (eGFR 101±28ml/min1.73m2), and R2* maps were determined on four coronal slices. In the CO-technique, R2* values were based on a semi-automatic procedure that divided each kidney in six equal layers, whereas in the ROI-technique, all circles (ROIs) were placed manually in the cortex and medulla. The mean R2* values as assessed by two independent investigators were compared. Results: With the CO-technique, inter-observer variability was 0.7%-1.9% across all layers in non-CKD, versus 1.6%-3.8% in CKD. With the ROI-technique, median variability for cortical and medullary R2* values was 3.6 and 6.8% in non-CKD, versus 4.7 and 12.5% in CKD; similar results were observed after furosemide. Conclusion: The CO-technique offers a new, investigator-independent, highly reproducible alternative to the ROI-based technique to estimate renal tissue oxygenation in CKD.
AB - Objectives: To assess inter-observer variability of renal blood oxygenation level-dependent MRI (BOLD-MRI) using a new method of analysis, called the concentric objects (CO) technique, in comparison with the classical ROI (region of interest)-based technique. Methods: MR imaging (3T) was performed before and after furosemide in 10 chronic kidney disease (CKD) patients (mean eGFR 43±24ml/min/1.73m2) and 10 healthy volunteers (eGFR 101±28ml/min1.73m2), and R2* maps were determined on four coronal slices. In the CO-technique, R2* values were based on a semi-automatic procedure that divided each kidney in six equal layers, whereas in the ROI-technique, all circles (ROIs) were placed manually in the cortex and medulla. The mean R2* values as assessed by two independent investigators were compared. Results: With the CO-technique, inter-observer variability was 0.7%-1.9% across all layers in non-CKD, versus 1.6%-3.8% in CKD. With the ROI-technique, median variability for cortical and medullary R2* values was 3.6 and 6.8% in non-CKD, versus 4.7 and 12.5% in CKD; similar results were observed after furosemide. Conclusion: The CO-technique offers a new, investigator-independent, highly reproducible alternative to the ROI-based technique to estimate renal tissue oxygenation in CKD.
KW - BOLD-MRI
KW - Chronic kidney disease
KW - Concentric objects
KW - Furosemide
KW - Imaging analysis
KW - Onion peel technique
KW - Region of interest
KW - Reproducibility
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U2 - 10.1016/j.mri.2014.12.002
DO - 10.1016/j.mri.2014.12.002
M3 - Article
C2 - 25523609
AN - SCOPUS:84924865175
SN - 0730-725X
VL - 33
SP - 253
EP - 261
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
IS - 3
ER -