A new technique with high reproducibility to estimate renal oxygenation using BOLD-MRI in chronic kidney disease

Maciej Piskunowicz, Lucie Hofmann, Emilie Zuercher, Isabelle Bassi, Bastien Milani, Matthias Stuber, Krzysztof Narkiewicz, Bruno Vogt, Michel Burnier, Menno Pruijm

Research output: Contribution to journalArticle

Abstract

Objectives: To assess inter-observer variability of renal blood oxygenation level-dependent MRI (BOLD-MRI) using a new method of analysis, called the concentric objects (CO) technique, in comparison with the classical ROI (region of interest)-based technique. Methods: MR imaging (3T) was performed before and after furosemide in 10 chronic kidney disease (CKD) patients (mean eGFR 43±24ml/min/1.73m2) and 10 healthy volunteers (eGFR 101±28ml/min1.73m2), and R2* maps were determined on four coronal slices. In the CO-technique, R2* values were based on a semi-automatic procedure that divided each kidney in six equal layers, whereas in the ROI-technique, all circles (ROIs) were placed manually in the cortex and medulla. The mean R2* values as assessed by two independent investigators were compared. Results: With the CO-technique, inter-observer variability was 0.7%-1.9% across all layers in non-CKD, versus 1.6%-3.8% in CKD. With the ROI-technique, median variability for cortical and medullary R2* values was 3.6 and 6.8% in non-CKD, versus 4.7 and 12.5% in CKD; similar results were observed after furosemide. Conclusion: The CO-technique offers a new, investigator-independent, highly reproducible alternative to the ROI-based technique to estimate renal tissue oxygenation in CKD.

Original languageEnglish (US)
Pages (from-to)253-261
Number of pages9
JournalMagnetic Resonance Imaging
Volume33
Issue number3
DOIs
StatePublished - Apr 1 2015
Externally publishedYes

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Oxygenation
Chronic Renal Insufficiency
Magnetic resonance imaging
Blood
Kidney
Observer Variation
Furosemide
Kidney Diseases
Research Personnel
Healthy Volunteers
Tissue
Imaging techniques

Keywords

  • BOLD-MRI
  • Chronic kidney disease
  • Concentric objects
  • Furosemide
  • Imaging analysis
  • Onion peel technique
  • Region of interest
  • Reproducibility

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Biomedical Engineering
  • Medicine(all)

Cite this

Piskunowicz, M., Hofmann, L., Zuercher, E., Bassi, I., Milani, B., Stuber, M., ... Pruijm, M. (2015). A new technique with high reproducibility to estimate renal oxygenation using BOLD-MRI in chronic kidney disease. Magnetic Resonance Imaging, 33(3), 253-261. https://doi.org/10.1016/j.mri.2014.12.002

A new technique with high reproducibility to estimate renal oxygenation using BOLD-MRI in chronic kidney disease. / Piskunowicz, Maciej; Hofmann, Lucie; Zuercher, Emilie; Bassi, Isabelle; Milani, Bastien; Stuber, Matthias; Narkiewicz, Krzysztof; Vogt, Bruno; Burnier, Michel; Pruijm, Menno.

In: Magnetic Resonance Imaging, Vol. 33, No. 3, 01.04.2015, p. 253-261.

Research output: Contribution to journalArticle

Piskunowicz, M, Hofmann, L, Zuercher, E, Bassi, I, Milani, B, Stuber, M, Narkiewicz, K, Vogt, B, Burnier, M & Pruijm, M 2015, 'A new technique with high reproducibility to estimate renal oxygenation using BOLD-MRI in chronic kidney disease', Magnetic Resonance Imaging, vol. 33, no. 3, pp. 253-261. https://doi.org/10.1016/j.mri.2014.12.002
Piskunowicz, Maciej ; Hofmann, Lucie ; Zuercher, Emilie ; Bassi, Isabelle ; Milani, Bastien ; Stuber, Matthias ; Narkiewicz, Krzysztof ; Vogt, Bruno ; Burnier, Michel ; Pruijm, Menno. / A new technique with high reproducibility to estimate renal oxygenation using BOLD-MRI in chronic kidney disease. In: Magnetic Resonance Imaging. 2015 ; Vol. 33, No. 3. pp. 253-261.
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abstract = "Objectives: To assess inter-observer variability of renal blood oxygenation level-dependent MRI (BOLD-MRI) using a new method of analysis, called the concentric objects (CO) technique, in comparison with the classical ROI (region of interest)-based technique. Methods: MR imaging (3T) was performed before and after furosemide in 10 chronic kidney disease (CKD) patients (mean eGFR 43±24ml/min/1.73m2) and 10 healthy volunteers (eGFR 101±28ml/min1.73m2), and R2* maps were determined on four coronal slices. In the CO-technique, R2* values were based on a semi-automatic procedure that divided each kidney in six equal layers, whereas in the ROI-technique, all circles (ROIs) were placed manually in the cortex and medulla. The mean R2* values as assessed by two independent investigators were compared. Results: With the CO-technique, inter-observer variability was 0.7{\%}-1.9{\%} across all layers in non-CKD, versus 1.6{\%}-3.8{\%} in CKD. With the ROI-technique, median variability for cortical and medullary R2* values was 3.6 and 6.8{\%} in non-CKD, versus 4.7 and 12.5{\%} in CKD; similar results were observed after furosemide. Conclusion: The CO-technique offers a new, investigator-independent, highly reproducible alternative to the ROI-based technique to estimate renal tissue oxygenation in CKD.",
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AU - Milani, Bastien

AU - Stuber, Matthias

AU - Narkiewicz, Krzysztof

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