A new system for catheter ablation of atrial fibrillation

Hugh Calkins, Jeffrey Hall, Kenneth Ellenbogen, Greg Walcott, Marshall Sherman, Wade Bowe, John Simpson, Tom Castellano, G. Neal Kay

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Increased attention is now being focused on developing new technologies to cure atrial fibrillation using catheter ablation techniques. The performance of a MAZE-type procedure using standard catheter ablation technologies is arduous and is associated with an unacceptable risk of complications. The Guidant Heart Rhythm Technologies Linear Ablation System was developed to create long transmural linear lesions. Unique features of this system include the availability of different preshaped multi-electrode steerable ablation catheters, the use of phased radiofrequency (RF) energy, and the control of RF output by varying the duty cycle. A prospective multicenter clinical trial to evaluate the safety and efficacy of a right atrial ablation procedure using this technology to treat atrial fibrillation is currently underway. To date, 15 patients have been enrolled and the procedure was acutely effective in 14 of 15 patients with no complications. Atrial fibrillation has recurred during short-term follow-up in 12 of 15 patients, a not surprising result, because this initial phase of testing involved only right-sided ablation. The early results of the phase I clinical trial confirm the findings of others that successful ablation of chronic atrial fibrillation is likely to require a left atrial approach. This clinical trial, as well as others that are currently underway, will be invaluable in the continuing development of catheter ablation of atrial fibrillation and, ultimately, in determining if the routine use of this therapeutic tool can become a reality.

Original languageEnglish (US)
Pages (from-to)227D-236D
JournalAmerican Journal of Cardiology
Issue number5 B
StatePublished - Mar 11 1999

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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