A new ring tossed into an old HAT

Alison E. Ringel, Cynthia Wolberger

Research output: Contribution to journalArticle

Abstract

p300 and CBP are multi-domain histone acetyltransferases (HATs) that regulate gene expression and are mutated in human diseases including cancer. Delvecchio and colleagues report the structure of the p300 catalytic core, revealing the presence of a previously unknown RING domain that regulates the enzyme's activity.

Original languageEnglish (US)
Pages (from-to)1479-1481
Number of pages3
JournalStructure
Volume21
Issue number9
DOIs
StatePublished - Sep 3 2013

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Histone Acetyltransferases
Catalytic Domain
Gene Expression
Enzymes
Neoplasms

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Cite this

A new ring tossed into an old HAT. / Ringel, Alison E.; Wolberger, Cynthia.

In: Structure, Vol. 21, No. 9, 03.09.2013, p. 1479-1481.

Research output: Contribution to journalArticle

Ringel, Alison E. ; Wolberger, Cynthia. / A new ring tossed into an old HAT. In: Structure. 2013 ; Vol. 21, No. 9. pp. 1479-1481.
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