A new method to assess metastatic potential of human prostate cancer: Relative nuclear roundness

D. A. Diamond, S. J. Berry, H. J. Jewett, J. C. Eggleston, D. S. Coffey

Research output: Contribution to journalArticle

Abstract

A new technique has been developed that helped in an accurate prediction of the prognosis of 27 patients with stages B1 and B2 prostatic cancer following radical prostatectomy. This method involves computer-assisted analysis of histological specimens of the primary lesion removed at the time of radical perineal prostatectomy. On the basis of a nuclear shape factor, known as nuclear roundness, we have been able to distinguish those tumors with a high metastatic potential from tumors that are less aggressive. This technique provides pathologists with quantitative information about the metastatic potential of a tumor, which may aid in the management of the individual patient.

Original languageEnglish (US)
Pages (from-to)729-734
Number of pages6
JournalUnknown Journal
Volume128
Issue number4
DOIs
StatePublished - Jan 1 1982

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ASJC Scopus subject areas

  • Urology

Cite this

Diamond, D. A., Berry, S. J., Jewett, H. J., Eggleston, J. C., & Coffey, D. S. (1982). A new method to assess metastatic potential of human prostate cancer: Relative nuclear roundness. Unknown Journal, 128(4), 729-734. https://doi.org/10.1016/S0022-5347(17)53158-4