A New Method for the Resolution of Racemic Carbonyl Compounds: Synthesis and Use of 4-(4-Carboxyphenyl)-semicarbazide

James K. Shillington, George S. Denning, William B. Greenough, Trafford Hill, O. Bertrand Ramsay

Research output: Contribution to journalArticlepeer-review

Abstract

A new approach has been developed for the resolution of carbonyl compounds possessing an asymmetric carbon atom by means of a bifunctional intermediate which possesses a free acid group and a group which reversibly condenses with the carbonyl compound. For this purpose, 4-(4-carboxyphenyl)-semicarbazide has been synthesized and its use assayed in a successful resolution of dl-3-methylcyclohexanone.

Original languageEnglish (US)
Pages (from-to)6551-6553
Number of pages3
JournalJournal of the American Chemical Society
Volume80
Issue number24
DOIs
StatePublished - Dec 1 1958
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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