A New Method for the Resolution of Racemic Carbonyl Compounds: Synthesis and Use of 4-(4-Carboxyphenyl)-semicarbazide

James K. Shillington; George S. Denning; William B. Greenough; Trafford Hill; O. Bertrand Ramsay

doi:10.1021/ja01557a025

A New Method for the Resolution of Racemic Carbonyl Compounds: Synthesis and Use of 4-(4-Carboxyphenyl)-semicarbazide

James K. Shillington, George S. Denning, William B. Greenough, Trafford Hill, O. Bertrand Ramsay

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A new approach has been developed for the resolution of carbonyl compounds possessing an asymmetric carbon atom by means of a bifunctional intermediate which possesses a free acid group and a group which reversibly condenses with the carbonyl compound. For this purpose, 4-(4-carboxyphenyl)-semicarbazide has been synthesized and its use assayed in a successful resolution of dl-3-methylcyclohexanone.

Original language	English (US)
Pages (from-to)	6551-6553
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	80
Issue number	24
DOIs	https://doi.org/10.1021/ja01557a025
State	Published - Dec 1 1958
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja01557a025

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AU - Denning, George S.

AU - Greenough, William B.

AU - Hill, Trafford

AU - Ramsay, O. Bertrand

PY - 1958/12/1

Y1 - 1958/12/1

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A New Method for the Resolution of Racemic Carbonyl Compounds: Synthesis and Use of 4-(4-Carboxyphenyl)-semicarbazide

Abstract

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