A new method for cardiac computed tomography regional function assessment

Stretch quantifier for endocardial engraved zones (SQUEEZ)

Amir Pourmorteza, Karl H. Schuleri, Daniel Herzka, Albert C. Lardo, Elliot R. McVeigh

Research output: Contribution to journalArticle

Abstract

Background-Quantitative assessment of regional myocardial function has important diagnostic implications in cardiac disease. Recent advances in CT imaging technology have allowed fine anatomic structures, such as endocardial trabeculae, to be resolved and potentially used as fiducial markers for tracking local wall deformations. We developed a method to detect and track such features on the endocardium to extract a metric that reflects local myocardial contraction. Methods and Results-First-pass CT images and contrast-enhanced cardiovascular magnetic resonance images were acquired in 8 infarcted and 3 healthy pigs. We tracked the left ventricle wall motion by segmenting the blood from myocardium and calculating trajectories of the endocardial features seen on the blood cast. The relative motions of these surface features were used to represent the local contraction of the endocardial surface with a metric we call Stretch Quantifier of Endocardial Engraved Zones (SQUEEZ). The average SQUEEZ value and the rate of change in SQUEEZ were calculated for both infarcted and healthy myocardial regions. SQUEEZ showed a significant difference between infarct and remote regions (P

Original languageEnglish (US)
Pages (from-to)243-250
Number of pages8
JournalCirculation: Cardiovascular Imaging
Volume5
Issue number2
DOIs
StatePublished - Mar 2012

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Tomography
Fiducial Markers
Myocardial Contraction
Endocardium
Heart Ventricles
Heart Diseases
Myocardium
Magnetic Resonance Spectroscopy
Swine
Technology

Keywords

  • Cardiac imaging techniques
  • Four-dimensional computed tomography
  • Ischemic heart disease
  • Magnetic resonance imaging
  • Myocardial contraction
  • Volumetric computed tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

A new method for cardiac computed tomography regional function assessment : Stretch quantifier for endocardial engraved zones (SQUEEZ). / Pourmorteza, Amir; Schuleri, Karl H.; Herzka, Daniel; Lardo, Albert C.; McVeigh, Elliot R.

In: Circulation: Cardiovascular Imaging, Vol. 5, No. 2, 03.2012, p. 243-250.

Research output: Contribution to journalArticle

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