A new metabolite of retinol: All-trans-4-oxo-retinol as a receptor activator and differentiation agent

Sharon A. Ross, Luigi M. De Luca

Research output: Contribution to journalReview articlepeer-review

Abstract

All-trans-4-oxo-retinol, a metabolite of retinol synthesized in mouse embryonal carcinoma F9 cells, is active in inducing differentiation of these cells. It also functions as a ligand of retinoic acid receptors and a transcriptional activator of reporter genes. These findings may dispel the notion that retinoic acids are the only transactivators of retinoid receptor-dependent pathways. However, there are weaknesses that need to be addressed in order to confirm the relevance of this retinol-mediated signaling pathway.

Original languageEnglish (US)
Pages (from-to)355-356
Number of pages2
JournalNutrition reviews
Volume54
Issue number11 I
DOIs
StatePublished - Nov 1996
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'A new metabolite of retinol: All-trans-4-oxo-retinol as a receptor activator and differentiation agent'. Together they form a unique fingerprint.

Cite this