A new member of the frizzled family from Drosophila functions as a wingless receptor

Purnima Bhanot, Marcel Brink, Cindy Harryman Samos, Jen Chih Hsieh, Yanshu Wang, Jennifer P. Macke, Deborah J Andrew, Jeremy Nathans, Roel Nusse

Research output: Contribution to journalArticle

Abstract

Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be identified. We show here that cultured Drosophila cells transfected with a novel member of the frizzled gene family in Drosophila, Dfz2, respond to added Wingless protein by elevating the level of the Armadillo protein. Moreover, Wingless binds to Drosophila or human cells expressing Dfz2. These data demonstrate that Dfz2 functions as a Wingless receptor, and they imply, in general, that Frizzled proteins are receptors for the Wnt signalling molecules.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
JournalNature
Volume382
Issue number6588
DOIs
StatePublished - Jul 18 1996

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Frizzled Receptors
Drosophila
Armadillo Domain Proteins
Genes
Cultured Cells
Proteins

ASJC Scopus subject areas

  • General

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Bhanot, P., Brink, M., Samos, C. H., Hsieh, J. C., Wang, Y., Macke, J. P., ... Nusse, R. (1996). A new member of the frizzled family from Drosophila functions as a wingless receptor. Nature, 382(6588), 225-231. https://doi.org/10.1038/382225a0

A new member of the frizzled family from Drosophila functions as a wingless receptor. / Bhanot, Purnima; Brink, Marcel; Samos, Cindy Harryman; Hsieh, Jen Chih; Wang, Yanshu; Macke, Jennifer P.; Andrew, Deborah J; Nathans, Jeremy; Nusse, Roel.

In: Nature, Vol. 382, No. 6588, 18.07.1996, p. 225-231.

Research output: Contribution to journalArticle

Bhanot, P, Brink, M, Samos, CH, Hsieh, JC, Wang, Y, Macke, JP, Andrew, DJ, Nathans, J & Nusse, R 1996, 'A new member of the frizzled family from Drosophila functions as a wingless receptor', Nature, vol. 382, no. 6588, pp. 225-231. https://doi.org/10.1038/382225a0
Bhanot P, Brink M, Samos CH, Hsieh JC, Wang Y, Macke JP et al. A new member of the frizzled family from Drosophila functions as a wingless receptor. Nature. 1996 Jul 18;382(6588):225-231. https://doi.org/10.1038/382225a0
Bhanot, Purnima ; Brink, Marcel ; Samos, Cindy Harryman ; Hsieh, Jen Chih ; Wang, Yanshu ; Macke, Jennifer P. ; Andrew, Deborah J ; Nathans, Jeremy ; Nusse, Roel. / A new member of the frizzled family from Drosophila functions as a wingless receptor. In: Nature. 1996 ; Vol. 382, No. 6588. pp. 225-231.
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