A new member of the frizzled family from Drosophila functions as a wingless receptor

Purnima Bhanot, Marcel Brink, Cindy Harryman Samos, Jen Chih Hsieh, Yanshu Wang, Jennifer P. Macke, Deborah Andrew, Jeremy Nathans, Roel Nusse

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Abstract

Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be identified. We show here that cultured Drosophila cells transfected with a novel member of the frizzled gene family in Drosophila, Dfz2, respond to added Wingless protein by elevating the level of the Armadillo protein. Moreover, Wingless binds to Drosophila or human cells expressing Dfz2. These data demonstrate that Dfz2 functions as a Wingless receptor, and they imply, in general, that Frizzled proteins are receptors for the Wnt signalling molecules.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
JournalNature
Volume382
Issue number6588
DOIs
StatePublished - Jul 18 1996

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Cite this

Bhanot, P., Brink, M., Samos, C. H., Hsieh, J. C., Wang, Y., Macke, J. P., Andrew, D., Nathans, J., & Nusse, R. (1996). A new member of the frizzled family from Drosophila functions as a wingless receptor. Nature, 382(6588), 225-231. https://doi.org/10.1038/382225a0