A new locus for autosomal dominant Stargardt-like disease maps to chromosome 4

Marina Kniazeva, Michael F. Chiang, Basil S Morgan, Alfred L. Anduze, Donald J Zack, Min Han, Kang Zhang

Research output: Contribution to journalArticle

Abstract

Stargardt disease (STGD) is the most common hereditary macular dystrophy and is characterized by decreased central vision, atrophy of the macula and underlying retinal-pigment epithelium, and frequent presence of prominent flecks in the posterior pole of the retina. STGD is most commonly inherited as an autosomal recessive trait, but many families have been described in which features of the disease are transmitted in an autosomal dominant manner. A recessive locus has been identified on chromosome 1p (STGD1), and dominant loci have been mapped to both chromosome 13q (STGD2) and chromosome 6q (STGD3). In this study, we describe a kindred with an autosomal dominant Stargardt-like phenotype. A genomewide search demonstrated linkage to a locus on chromosome 4p, with a maximum LOD score of 5.12 at a recombination fraction of .00, for marker D4S403. Analysis of extended haplotypes localized the disease gene to an ~12-cM interval between loci D4S1582 and D4S2397. Therefore, this kindred establishes a new dominant Stargardt-like locus, STGD4.

Original languageEnglish (US)
Pages (from-to)1394-1399
Number of pages6
JournalAmerican Journal of Human Genetics
Volume64
Issue number5
DOIs
Publication statusPublished - 1999
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

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