A new interpretative paradigm for conformational Protein Diseases

Luigi Francesco Agnati, Diego Guidolin, Amina S. Woods, Francisco Ciruela, Chiara Carone, Annamaria Vallelunga, Dasiel Oscar Borroto Escuela, Susanna Genedani, Kjell Fuxe

Research output: Contribution to journalArticlepeer-review


Conformational Protein Diseases (CPDs) comprise over forty clinically and pathologically diverse disorders in which specific altered proteins accumulate in cells or tissues of the body. The most studied are Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, prion diseases, inclusion body myopathy, and the systemic amyloidoses. They are characterised by three dimensional conformational alterations, which are often rich in β structure. Proteins in this non-native conformation are highly stable, resistant to degradation, and have an enhanced tendency to aggregate with like protein molecules. The misfolded proteins can impart their anomalous properties to soluble, monomeric proteins with the same amino acid sequence by a process that has been likened to seeded crystallization. However, these potentially pathogenic proteins also have important physiological actions, which have not completely characterized. This opens up the question of what process transforms physiological actions into pathological actions and most intriguing, is why potentially dangerous proteins have been maintained during evolution and are present from yeasts to humans. In the present paper, we introduce the concept of mis-exaptation and of mis-tinkering since they may help in clarifying some of the double edged sword aspects of these proteins. Against this background an original interpretative paradigm for CPDs will be given in the frame of the previously proposed Red Queen Theory of Aging.

Original languageEnglish (US)
Pages (from-to)141-160
Number of pages20
JournalCurrent Protein and Peptide Science
Issue number2
StatePublished - 2013
Externally publishedYes


  • Aging
  • Exaptation
  • Neurodegenerative diseases
  • Prions
  • Protein aggregation
  • Protein conformation
  • Tinkering

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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