TY - JOUR
T1 - A new immunohistochemistry prognostic score (IPS) for recurrence and survival in resected pancreatic neuroendocrine tumors (PanNET)
AU - Viúdez, Antonio
AU - Carvalho, Filipe L.F.
AU - Maleki, Zahra
AU - Zahurak, Marianna
AU - Laheru, Daniel
AU - Stark, Alejandro
AU - Azad, Nilofer Z.
AU - Wolfgang, Christopher L.
AU - Baylin, Stephen
AU - Herman, James G.
AU - De Jesus-Acosta, Ana
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Pancreatic neuroendocrine tumor (PanNET) is a neoplastic entity in which few prognostic factors are well-known. Here, we aimed to evaluate the prognostic significance of N-myc downstream-regulated gen-1 (NDRG-1), O6-methylguanine DNA methyltransferase (MGMT) and Pleckstrin homology-like domain family A member 3 (PHLDA-3) by immunohistochemistry (IHC) and methylation analysis in 92 patients with resected PanNET and follow-up longer than 24 months. In multivariate analyses, ki-67 and our immunohistochemistry prognostic score (IPS-based on MGMT, NDRG-1 and PHLDA-3 IHC expression) were independent prognostic factors for disease-free-survival (DFS), while age and IPS were independent prognostic factors for overall survival (OS). Our IPS could be a useful prognostic biomarker for recurrence and survival in patients following resection for PanNET.
AB - Pancreatic neuroendocrine tumor (PanNET) is a neoplastic entity in which few prognostic factors are well-known. Here, we aimed to evaluate the prognostic significance of N-myc downstream-regulated gen-1 (NDRG-1), O6-methylguanine DNA methyltransferase (MGMT) and Pleckstrin homology-like domain family A member 3 (PHLDA-3) by immunohistochemistry (IHC) and methylation analysis in 92 patients with resected PanNET and follow-up longer than 24 months. In multivariate analyses, ki-67 and our immunohistochemistry prognostic score (IPS-based on MGMT, NDRG-1 and PHLDA-3 IHC expression) were independent prognostic factors for disease-free-survival (DFS), while age and IPS were independent prognostic factors for overall survival (OS). Our IPS could be a useful prognostic biomarker for recurrence and survival in patients following resection for PanNET.
KW - Immunohistochemistry
KW - MGMT
KW - NDRG-1
KW - PHLDA-3
KW - Pancreatic neuroendocrine tumor
UR - http://www.scopus.com/inward/record.url?scp=84967164136&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84967164136&partnerID=8YFLogxK
U2 - 10.18632/oncotarget.7436
DO - 10.18632/oncotarget.7436
M3 - Article
C2 - 26894863
AN - SCOPUS:84967164136
SN - 1949-2553
VL - 7
SP - 24950
EP - 24961
JO - Oncotarget
JF - Oncotarget
IS - 18
ER -