A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays

Phyllis C. Leppert, William H. Catherino, James H. Segars

Research output: Contribution to journalArticle


This article will discuss some recent insights based on our microarray studies that have emphasized the role the extracellular matrix, transforming growth factor beta, and collagen structure in fibroid formation. These studies led to appreciation of molecular similarities between fibroids and keloids. Collectively, these observations suggest a model of fibroid development based on an abnormal response to tissue repair, resulting in disordered healing and formation of an altered extracellular matrix.

Original languageEnglish (US)
Pages (from-to)415-420
Number of pages6
JournalAmerican journal of obstetrics and gynecology
Issue number2
StatePublished - Aug 1 2006



  • Collagen
  • Extracellular matrix
  • Fibroids
  • Keloid
  • Leiomyoma
  • Microarray

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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