A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays

Phyllis C. Leppert, William H. Catherino, James Segars

Research output: Contribution to journalArticle

Abstract

This article will discuss some recent insights based on our microarray studies that have emphasized the role the extracellular matrix, transforming growth factor beta, and collagen structure in fibroid formation. These studies led to appreciation of molecular similarities between fibroids and keloids. Collectively, these observations suggest a model of fibroid development based on an abnormal response to tissue repair, resulting in disordered healing and formation of an altered extracellular matrix.

Original languageEnglish (US)
Pages (from-to)415-420
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume195
Issue number2
DOIs
StatePublished - Aug 2006
Externally publishedYes

Fingerprint

Leiomyoma
Gene Expression Profiling
Extracellular Matrix
Keloid
Transforming Growth Factor beta
Collagen

Keywords

  • Collagen
  • Extracellular matrix
  • Fibroids
  • Keloid
  • Leiomyoma
  • Microarray

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays. / Leppert, Phyllis C.; Catherino, William H.; Segars, James.

In: American Journal of Obstetrics and Gynecology, Vol. 195, No. 2, 08.2006, p. 415-420.

Research output: Contribution to journalArticle

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