A new group of neurons in hypothalamus containing phenylethanolamine N-methyltransferase (PNMT) but not tyrosine hydroxylase

C. A. Ross, D. A. Ruggiero, M. P. Meeley, D. H. Park, T. H. Joh, D. J. Reis

Research output: Contribution to journalArticlepeer-review

Abstract

Intraventricular injection of colchicine in rat results in the appearance within hypothalamus of numerous neurons containing the adrenaline-synthesizing enzyme, phenylethanolamine N-methyltransferase, but not the other catecholamine biosynthetic enzymes. Increased PNMT staining in hypothalamus was paralleled by an increase in PNMT activity measured in micropunch preparations. Immunotitration demonstrated that this increase was due to accumulation of specific enzyme protein. The finding that hypothalamic neurons express PNMT without tyrosine hydroxylase suggests that such neurons may produce methylated amines other than adrenaline.

Original languageEnglish (US)
Pages (from-to)349-353
Number of pages5
JournalBrain research
Volume306
Issue number1-2
DOIs
StatePublished - Jul 23 1984
Externally publishedYes

Keywords

  • PNMT neuron
  • colchicine
  • hypothalamus
  • rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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