Abstract
Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by impairing motor-vocal tics. Locating genetic loci by associating the phenotype with DNA translocations, inversions, gain or losses, State et al. identified SLITRK1 as a candidate gene in an individual with GTS and inv(13) (q31.1; q33.1). This gene was also associated with abnormal axonal-dendritic development in embryonic mouse cells. Although SLITRK1 is not a major causal gene for GTS, it can shed light on our understanding of the gene-based neural correlates of this disease.
Original language | English (US) |
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Pages (from-to) | 291-293 |
Number of pages | 3 |
Journal | Trends in Genetics |
Volume | 22 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1 2006 |
ASJC Scopus subject areas
- Genetics