A new fold on an old story: Attachment of intermediate filaments to desmosomes

Pierre A. Coulombe

Research output: Contribution to journalShort survey


Desmoplakin is a major and essential constituent of the interface between the transmembrane glycoproteins mediating adhesion and the intermediate filament cytoskeleton in the cell interior. The structures of two desmoplakin domains that participate in intermediate filament binding reveal that a unique 38-amino acid repeat-containing domain shared with related proteins packs in a novel globular fold.

Original languageEnglish (US)
Pages (from-to)560-562
Number of pages3
JournalNature structural biology
Issue number8
StatePublished - Aug 7 2002


ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics

Cite this