A new dimension of 1H-NMR spectroscopy in assessment of liver graft dysfunction

H. K. Singh, S. K. Yachha, Rajan Saxena, Ashish Gupta, G. A. Nagana Gowda, M. Bhandari, C. L. Khetrapal

Research output: Contribution to journalArticlepeer-review

Abstract

High-resolution 1H-NMR spectroscopy of serum and urine samples of an 11-year-old male living related orthotopic liver transplant recipient is reported. Serum glutamine increased to abnormal levels along with simultaneous abnormal excretion of urinary glutamine post-transplantation. High levels of glutamine in both blood and urine and concomitant reduced urea levels in urine were found to be evidence of impairment in urea cycle and compatible with persistently abnormal graft function. Thus glutamine levels in serum and urine, and urea in the urine as observed by 1H-NMR spectroscopy highlight their important roles in monitoring liver graft function; increased glutamine levels lead to brain damage, if untreated.

Original languageEnglish (US)
Pages (from-to)185-188
Number of pages4
JournalNMR in biomedicine
Volume16
Issue number4
DOIs
StatePublished - Jun 1 2003

Keywords

  • Acute liver cell failure
  • Hepatic encephalopathy
  • One- and two-dimensional NMR spectroscopy
  • Orthotopic liver transplant
  • Urea cycle

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

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