A new dimension of 1H-NMR spectroscopy in assessment of liver graft dysfunction

H. K. Singh; S. K. Yachha; Rajan Saxena; Ashish Gupta; G. A. Nagana Gowda; M. Bhandari; C. L. Khetrapal

doi:10.1002/nbm.829

A new dimension of ¹H-NMR spectroscopy in assessment of liver graft dysfunction

H. K. Singh, S. K. Yachha, Rajan Saxena, Ashish Gupta, G. A. Nagana Gowda, M. Bhandari, C. L. Khetrapal

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

High-resolution ¹H-NMR spectroscopy of serum and urine samples of an 11-year-old male living related orthotopic liver transplant recipient is reported. Serum glutamine increased to abnormal levels along with simultaneous abnormal excretion of urinary glutamine post-transplantation. High levels of glutamine in both blood and urine and concomitant reduced urea levels in urine were found to be evidence of impairment in urea cycle and compatible with persistently abnormal graft function. Thus glutamine levels in serum and urine, and urea in the urine as observed by ¹H-NMR spectroscopy highlight their important roles in monitoring liver graft function; increased glutamine levels lead to brain damage, if untreated.

Original language	English (US)
Pages (from-to)	185-188
Number of pages	4
Journal	NMR in biomedicine
Volume	16
Issue number	4
DOIs	https://doi.org/10.1002/nbm.829
State	Published - Jun 2003
Externally published	Yes

Keywords

Acute liver cell failure
Hepatic encephalopathy
One- and two-dimensional NMR spectroscopy
Orthotopic liver transplant
Urea cycle

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Spectroscopy

Access to Document

10.1002/nbm.829

Cite this

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title = "A new dimension of 1H-NMR spectroscopy in assessment of liver graft dysfunction",

abstract = "High-resolution 1H-NMR spectroscopy of serum and urine samples of an 11-year-old male living related orthotopic liver transplant recipient is reported. Serum glutamine increased to abnormal levels along with simultaneous abnormal excretion of urinary glutamine post-transplantation. High levels of glutamine in both blood and urine and concomitant reduced urea levels in urine were found to be evidence of impairment in urea cycle and compatible with persistently abnormal graft function. Thus glutamine levels in serum and urine, and urea in the urine as observed by 1H-NMR spectroscopy highlight their important roles in monitoring liver graft function; increased glutamine levels lead to brain damage, if untreated.",

keywords = "Acute liver cell failure, Hepatic encephalopathy, One- and two-dimensional NMR spectroscopy, Orthotopic liver transplant, Urea cycle",

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AU - Singh, H. K.

AU - Yachha, S. K.

AU - Saxena, Rajan

AU - Gupta, Ashish

AU - Nagana Gowda, G. A.

AU - Bhandari, M.

AU - Khetrapal, C. L.

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AB - High-resolution 1H-NMR spectroscopy of serum and urine samples of an 11-year-old male living related orthotopic liver transplant recipient is reported. Serum glutamine increased to abnormal levels along with simultaneous abnormal excretion of urinary glutamine post-transplantation. High levels of glutamine in both blood and urine and concomitant reduced urea levels in urine were found to be evidence of impairment in urea cycle and compatible with persistently abnormal graft function. Thus glutamine levels in serum and urine, and urea in the urine as observed by 1H-NMR spectroscopy highlight their important roles in monitoring liver graft function; increased glutamine levels lead to brain damage, if untreated.

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KW - One- and two-dimensional NMR spectroscopy

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