A new class of steroids inhibits angiogenesis in the presence of hepanin or a heparin fragment

Rosa Crum, Sandor Szabo, Judah Folkman

Research output: Contribution to journalArticlepeer-review

Abstract

Steroids that lack glucocorticoid or mineralocorticoid activity were found to inhibit angiogenesis in the presence of heparin or specific heparin fragments. This newly discovered steroid function appears to be governed by distinct structural configurations ofthe pregnane nucleus. These compounds are here named angiostatic steroids.

Original languageEnglish (US)
Pages (from-to)1375-1378
Number of pages4
JournalScience
Volume230
Issue number4732
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • General

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