A new chapter in the transcription SAGA

Nadine L. Samara, Cynthia Wolberger

Research output: Contribution to journalArticle

Abstract

Eukaryotic transcriptional coactivators are multi-subunit complexes that both modify chromatin and recognize histone modifications. Until recently, structural information on these large complexes has been limited to isolated enzymatic domains or chromatin-binding motifs. This review summarizes recent structural studies of the SAGA coactivator complex that have greatly advanced our understanding of the interplay between its different subunits. The structure of the four-protein SAGA deubiquitinating module has provided a first glimpse of the larger organization of a coactivator complex, and illustrates how interdependent subunits interact with each other to form an active and functional enzyme complex. In addition, structures of the histone binding domains of ATXN7 and Sgf29 shed light on the interactions with chromatin that help recruit the SAGA complex.

Original languageEnglish (US)
Pages (from-to)767-774
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume21
Issue number6
DOIs
StatePublished - Dec 2011
Externally publishedYes

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Chromatin
Histone Code
Histones
Enzymes
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Cite this

A new chapter in the transcription SAGA. / Samara, Nadine L.; Wolberger, Cynthia.

In: Current Opinion in Structural Biology, Vol. 21, No. 6, 12.2011, p. 767-774.

Research output: Contribution to journalArticle

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