A New Approach to the Problem of Retinal Neovascularization

Arnall Patz; Steven Brem; Daniel Finkelstein; Chung Ho Chen; Gerard Lutty; Alonzo Bennett; W. Ronald Coughlin; Jeffrey Gardner

doi:10.1016/S0161-6420(78)35640-2

A New Approach to the Problem of Retinal Neovascularization

Arnall Patz, Steven Brem, Daniel Finkelstein, Chung Ho Chen, Gerard Lutty, Alonzo Bennett, W. Ronald Coughlin, Jeffrey Gardner

School of Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Tumor cells introduced into the rabbit vitreous produced a form of retinal neovascularization, but only when the tumor cells were in direct contact with the vascularized retina. This contrasted with the production of neovascularization at a distance of several millimeters in other angiogenesis models. An extract of adult rabbit vitreous was found to inhibit the growth of limbal neovascularization induced by tumors implanted in the rabbit corneal stroma. The experimental model of retrolental fibroplasia provides a bioassay to investigate further the apparent inhibitory substances in the vitreous.

Original language	English (US)
Pages (from-to)	626-637
Number of pages	12
Journal	Ophthalmology
Volume	85
Issue number	6
DOIs	https://doi.org/10.1016/S0161-6420(78)35640-2
State	Published - Jan 1 1978

ASJC Scopus subject areas

Ophthalmology

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10.1016/S0161-6420(78)35640-2

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title = "A New Approach to the Problem of Retinal Neovascularization",

abstract = "Tumor cells introduced into the rabbit vitreous produced a form of retinal neovascularization, but only when the tumor cells were in direct contact with the vascularized retina. This contrasted with the production of neovascularization at a distance of several millimeters in other angiogenesis models. An extract of adult rabbit vitreous was found to inhibit the growth of limbal neovascularization induced by tumors implanted in the rabbit corneal stroma. The experimental model of retrolental fibroplasia provides a bioassay to investigate further the apparent inhibitory substances in the vitreous.",

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AU - Brem, Steven

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AU - Chen, Chung Ho

AU - Lutty, Gerard

AU - Bennett, Alonzo

AU - Coughlin, W. Ronald

AU - Gardner, Jeffrey

PY - 1978/1/1

Y1 - 1978/1/1

N2 - Tumor cells introduced into the rabbit vitreous produced a form of retinal neovascularization, but only when the tumor cells were in direct contact with the vascularized retina. This contrasted with the production of neovascularization at a distance of several millimeters in other angiogenesis models. An extract of adult rabbit vitreous was found to inhibit the growth of limbal neovascularization induced by tumors implanted in the rabbit corneal stroma. The experimental model of retrolental fibroplasia provides a bioassay to investigate further the apparent inhibitory substances in the vitreous.

AB - Tumor cells introduced into the rabbit vitreous produced a form of retinal neovascularization, but only when the tumor cells were in direct contact with the vascularized retina. This contrasted with the production of neovascularization at a distance of several millimeters in other angiogenesis models. An extract of adult rabbit vitreous was found to inhibit the growth of limbal neovascularization induced by tumors implanted in the rabbit corneal stroma. The experimental model of retrolental fibroplasia provides a bioassay to investigate further the apparent inhibitory substances in the vitreous.

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A New Approach to the Problem of Retinal Neovascularization

Abstract

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