@article{7c2bee1d3e2845e0a4195515f768dc02,
title = "A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination",
abstract = "The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P 3 is sufficient to trigger all steps of myelination.",
author = "Sandra Goebbels and Wieser, {Georg L.} and Alexander Pieper and Sonia Spitzer and Bettina Weege and Kuo Yan and Edgar, {Julia M.} and Oleksandr Yagensky and Wichert, {Sven P.} and Amit Agarwal and Khalad Karram and Nicolas Renier and Marc Tessier-Lavigne and Rossner, {Moritz J.} and K{\'a}rad{\'o}ttir, {Ragnhildur Th{\'o}ra} and Nave, {Klaus Armin}",
note = "Funding Information: We are grateful to A. Fahrenholz, U. Bode, C. Stuenkel and H.N. Hidaji for technical support and thank T. Ruhwedel and W. Moebius for help with electron microscopy. We thank U. F{\"u}nfschilling and L. Reichardt (University of California, San Francisco) for Tg(ma6)-Cre mice, H. Wu (University of California at Los Angeles School of Medicine) for Pten loxP-flanked mice, M. Sendtner (University of W{\"u}rzburg) for Bdnf loxP-flanked mice, C. Birchmeier (Max-Delbr{\"u}ck-Center for Molecular Medicine, Berlin) for Nrg1 loxP-flanked mice, P. Soriano (Icahn School of Medicine at Mount Sinai, New York) for Rosa26-lacZ reporter mice, J. Trotter (Johannes Gutenberg University, Mainz) for Ng2-EYFP mutants, F. Kirchhoff (University of Saarland, Homburg) for Plp1-DsRed transgenic mice, B. Emery (Oregon Health and Science University, Portland) for a Myrf in situ hybridization probe, and S. Ghandour (University of Strasbourg) and J. Alberta (Dana-Farber Cancer Institute, Boston) for primary antibodies. This work was supported by grants from the German Research Foundation (KFO241 to M.J.R., GO 2463/1-1 to S.G. and SPP-1172 to K.-A.N.) and by an ERC Advanced grant to K.-A.N.",
year = "2017",
month = jan,
day = "1",
doi = "10.1038/nn.4425",
language = "English (US)",
volume = "20",
pages = "10--15",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "1",
}