A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination

Sandra Goebbels, Georg L. Wieser, Alexander Pieper, Sonia Spitzer, Bettina Weege, Kuo Yan, Julia M. Edgar, Oleksandr Yagensky, Sven P. Wichert, Amit Agarwal, Khalad Karram, Nicolas Renier, Marc Tessier-Lavigne, Moritz J. Rossner, Ragnhildur Thóra Káradóttir, Klaus Armin Nave

Research output: Contribution to journalArticlepeer-review

Abstract

The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P 3 is sufficient to trigger all steps of myelination.

Original languageEnglish (US)
Pages (from-to)10-15
Number of pages6
JournalNature neuroscience
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2017

ASJC Scopus subject areas

  • Neuroscience(all)

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