A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination

Sandra Goebbels, Georg L. Wieser, Alexander Pieper, Sonia Spitzer, Bettina Weege, Kuo Yan, Julia M. Edgar, Oleksandr Yagensky, Sven P. Wichert, Amit Agarwal, Khalad Karram, Nicolas Renier, Marc Tessier-Lavigne, Moritz J. Rossner, Ragnhildur Thóra Káradóttir, Klaus Armin Nave

Research output: Contribution to journalArticle

Abstract

The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P 3 is sufficient to trigger all steps of myelination.

LanguageEnglish (US)
Pages10-15
Number of pages6
JournalNature Neuroscience
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

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Oligodendroglia
Regulator Genes
Phosphatidylinositols
Axons
Cell Differentiation
Stem Cells
Gene Expression
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Goebbels, S., Wieser, G. L., Pieper, A., Spitzer, S., Weege, B., Yan, K., ... Nave, K. A. (2017). A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination. Nature Neuroscience, 20(1), 10-15. DOI: 10.1038/nn.4425

A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination. / Goebbels, Sandra; Wieser, Georg L.; Pieper, Alexander; Spitzer, Sonia; Weege, Bettina; Yan, Kuo; Edgar, Julia M.; Yagensky, Oleksandr; Wichert, Sven P.; Agarwal, Amit; Karram, Khalad; Renier, Nicolas; Tessier-Lavigne, Marc; Rossner, Moritz J.; Káradóttir, Ragnhildur Thóra; Nave, Klaus Armin.

In: Nature Neuroscience, Vol. 20, No. 1, 01.01.2017, p. 10-15.

Research output: Contribution to journalArticle

Goebbels, S, Wieser, GL, Pieper, A, Spitzer, S, Weege, B, Yan, K, Edgar, JM, Yagensky, O, Wichert, SP, Agarwal, A, Karram, K, Renier, N, Tessier-Lavigne, M, Rossner, MJ, Káradóttir, RT & Nave, KA 2017, 'A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination' Nature Neuroscience, vol 20, no. 1, pp. 10-15. DOI: 10.1038/nn.4425
Goebbels S, Wieser GL, Pieper A, Spitzer S, Weege B, Yan K et al. A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination. Nature Neuroscience. 2017 Jan 1;20(1):10-15. Available from, DOI: 10.1038/nn.4425
Goebbels, Sandra ; Wieser, Georg L. ; Pieper, Alexander ; Spitzer, Sonia ; Weege, Bettina ; Yan, Kuo ; Edgar, Julia M. ; Yagensky, Oleksandr ; Wichert, Sven P. ; Agarwal, Amit ; Karram, Khalad ; Renier, Nicolas ; Tessier-Lavigne, Marc ; Rossner, Moritz J. ; Káradóttir, Ragnhildur Thóra ; Nave, Klaus Armin. / A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination. In: Nature Neuroscience. 2017 ; Vol. 20, No. 1. pp. 10-15
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