@article{7c2bee1d3e2845e0a4195515f768dc02,
title = "A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination",
abstract = "The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P 3 is sufficient to trigger all steps of myelination.",
author = "Sandra Goebbels and Wieser, {Georg L.} and Alexander Pieper and Sonia Spitzer and Bettina Weege and Kuo Yan and Edgar, {Julia M.} and Oleksandr Yagensky and Wichert, {Sven P.} and Amit Agarwal and Khalad Karram and Nicolas Renier and Marc Tessier-Lavigne and Rossner, {Moritz J.} and K{\'a}rad{\'o}ttir, {Ragnhildur Th{\'o}ra} and Nave, {Klaus Armin}",
note = "Funding Information: We are grateful to A. Fahrenholz, U. Bode, C. Stuenkel and H.N. Hidaji for technical support and thank T. Ruhwedel and W. Moebius for help with electron microscopy. We thank U. F?nfschilling and L. Reichardt (University of California, San Francisco) for Tg(ma6)-Cre mice, H. Wu (University of California at Los Angeles School of Medicine) for Pten loxP-flanked mice, M. Sendtner (University of W?rzburg) for Bdnf loxP-flanked mice, C. Birchmeier (Max-Delbr?ck-Center for Molecular Medicine, Berlin) for Nrg1 loxP-flanked mice, P. Soriano (Icahn School of Medicine at Mount Sinai, New York) for Rosa26-lacZ reporter mice, J. Trotter (Johannes Gutenberg University, Mainz) for Ng2-EYFP mutants, F. Kirchhoff (University of Saarland, Homburg) for Plp1-DsRed transgenic mice, B. Emery (Oregon Health and Science University, Portland) for a Myrf in situ hybridization probe, and S. Ghandour (University of Strasbourg) and J. Alberta (Dana-Farber Cancer Institute, Boston) for primary antibodies. This work was supported by grants from the German Research Foundation (KFO241 to M.J.R., GO 2463/1-1 to S.G. and SPP-1172 to K.-A.N.) and by an ERC Advanced grant to K.-A.N. Funding Information: We are grateful to A. Fahrenholz, U. Bode, C. Stuenkel and H.N. Hidaji for technical support and thank T. Ruhwedel and W. Moebius for help with electron microscopy. We thank U. F{\"u}nfschilling and L. Reichardt (University of California, San Francisco) for Tg(ma6)-Cre mice, H. Wu (University of California at Los Angeles School of Medicine) for Pten loxP-flanked mice, M. Sendtner (University of W{\"u}rzburg) for Bdnf loxP-flanked mice, C. Birchmeier (Max-Delbr{\"u}ck-Center for Molecular Medicine, Berlin) for Nrg1 loxP-flanked mice, P. Soriano (Icahn School of Medicine at Mount Sinai, New York) for Rosa26-lacZ reporter mice, J. Trotter (Johannes Gutenberg University, Mainz) for Ng2-EYFP mutants, F. Kirchhoff (University of Saarland, Homburg) for Plp1-DsRed transgenic mice, B. Emery (Oregon Health and Science University, Portland) for a Myrf in situ hybridization probe, and S. Ghandour (University of Strasbourg) and J. Alberta (Dana-Farber Cancer Institute, Boston) for primary antibodies. This work was supported by grants from the German Research Foundation (KFO241 to M.J.R., GO 2463/1-1 to S.G. and SPP-1172 to K.-A.N.) and by an ERC Advanced grant to K.-A.N. Publisher Copyright: {\textcopyright} 2017 Nature America, Inc., part of Springer Nature. All rights reserved.",
year = "2017",
month = jan,
day = "1",
doi = "10.1038/nn.4425",
language = "English (US)",
volume = "20",
pages = "10--15",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "1",
}