TY - JOUR
T1 - A neural signaling triumvirate that influences ageing and age-related disease
T2 - Insulin/IGF-1, BDNF and serotonin
AU - Mattson, Mark P.
AU - Maudsley, Stuart
AU - Martin, Bronwen
PY - 2004/11
Y1 - 2004/11
N2 - The ageing process and its associated diseases all involve perturbed energy metabolism, oxidative damage, and an impaired ability of the organism and its cells to cope with adversity. We propose that some specific signaling pathways in the brain may be important determinants of health during ageing. Among such specific signaling modalities are those activated in neurons by insulin-like growth factors (IGFs), brain-derived neurotrophic factor (BDNF) and serotonin. This triumvirate may be particularly important because of their cooperative influence on energy metabolism, food intake, stress responses and cardiovascular function. The health benefits to the periphery and central nervous system of dietary restriction and exercise may be mediated by this triumvirate of signals in the brain. At the molecular level, BDNF, serotonin and IGFs can all stimulate the production of proteins involved in cellular stress adaptation, growth and repair, neurogenesis, learning and memory and cell survival. The importance of this triumvirate is emphasized when it is seen that their general roles in energy metabolism, stress adaptation and disease resistance are conserved among diverse organisms consistent with important roles in the ageing process.
AB - The ageing process and its associated diseases all involve perturbed energy metabolism, oxidative damage, and an impaired ability of the organism and its cells to cope with adversity. We propose that some specific signaling pathways in the brain may be important determinants of health during ageing. Among such specific signaling modalities are those activated in neurons by insulin-like growth factors (IGFs), brain-derived neurotrophic factor (BDNF) and serotonin. This triumvirate may be particularly important because of their cooperative influence on energy metabolism, food intake, stress responses and cardiovascular function. The health benefits to the periphery and central nervous system of dietary restriction and exercise may be mediated by this triumvirate of signals in the brain. At the molecular level, BDNF, serotonin and IGFs can all stimulate the production of proteins involved in cellular stress adaptation, growth and repair, neurogenesis, learning and memory and cell survival. The importance of this triumvirate is emphasized when it is seen that their general roles in energy metabolism, stress adaptation and disease resistance are conserved among diverse organisms consistent with important roles in the ageing process.
KW - Autonomic nervous system
KW - CREB
KW - Hippocampus
KW - Hypothalamus
KW - PI3 kinase
KW - Stress response
UR - http://www.scopus.com/inward/record.url?scp=8444250215&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=8444250215&partnerID=8YFLogxK
U2 - 10.1016/j.arr.2004.08.001
DO - 10.1016/j.arr.2004.08.001
M3 - Article
C2 - 15541711
AN - SCOPUS:8444250215
SN - 1568-1637
VL - 3
SP - 445
EP - 464
JO - Ageing Research Reviews
JF - Ageing Research Reviews
IS - 4
ER -