TY - JOUR
T1 - A network map of Interleukin-10 signaling pathway
AU - Verma, Renu
AU - Balakrishnan, Lavanya
AU - Sharma, Kusum
AU - Khan, Aafaque Ahmad
AU - Advani, Jayshree
AU - Gowda, Harsha
AU - Tripathy, Srikanth Prasad
AU - Suar, Mrutyunjay
AU - Pandey, Akhilesh
AU - Gandotra, Sheetal
AU - Prasad, T. S Keshava
AU - Shankar, Subramanian
PY - 2015/8/8
Y1 - 2015/8/8
N2 - Interleukin-10 (IL-10) is an anti-inflammatory cytokine with important immunoregulatory functions. It is primarily secreted by antigen-presenting cells such as activated T-cells, monocytes, B-cells and macrophages. In biologically functional form, it exists as a homodimer that binds to tetrameric heterodimer IL-10 receptor and induces downstream signaling. IL-10 is associated with survival, proliferation and anti-apoptotic activities of various cancers such as Burkitt lymphoma, non-Hodgkins lymphoma and non-small scell lung cancer. In addition, it plays a central role in survival and persistence of intracellular pathogens such as Leishmania donovani, Mycobacterium tuberculosis and Trypanosoma cruzi inside the host. The signaling mechanisms of IL-10 cytokine are not well explored and a well annotated pathway map has been lacking. To this end, we developed a pathway resource by manually annotating the IL-10 induced signaling molecules derived from literature. The reactions were categorized under molecular associations, activation/inhibition, catalysis, transport and gene regulation. In all, 37 molecules and 76 reactions were annotated. The IL-10 signaling pathway can be freely accessed through NetPath, a resource of signal transduction pathways previously developed by our group.
AB - Interleukin-10 (IL-10) is an anti-inflammatory cytokine with important immunoregulatory functions. It is primarily secreted by antigen-presenting cells such as activated T-cells, monocytes, B-cells and macrophages. In biologically functional form, it exists as a homodimer that binds to tetrameric heterodimer IL-10 receptor and induces downstream signaling. IL-10 is associated with survival, proliferation and anti-apoptotic activities of various cancers such as Burkitt lymphoma, non-Hodgkins lymphoma and non-small scell lung cancer. In addition, it plays a central role in survival and persistence of intracellular pathogens such as Leishmania donovani, Mycobacterium tuberculosis and Trypanosoma cruzi inside the host. The signaling mechanisms of IL-10 cytokine are not well explored and a well annotated pathway map has been lacking. To this end, we developed a pathway resource by manually annotating the IL-10 induced signaling molecules derived from literature. The reactions were categorized under molecular associations, activation/inhibition, catalysis, transport and gene regulation. In all, 37 molecules and 76 reactions were annotated. The IL-10 signaling pathway can be freely accessed through NetPath, a resource of signal transduction pathways previously developed by our group.
KW - Co-stimulatory molecules
KW - Interferon-gamma (IFN-γ)
KW - Lipopolysaccharides
KW - NetSlim
KW - Pro-inflammatory cytokines
KW - Protein-protein interactions
KW - Systems biology markup language
KW - Translocation
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U2 - 10.1007/s12079-015-0302-x
DO - 10.1007/s12079-015-0302-x
M3 - Article
C2 - 26253919
AN - SCOPUS:84938801670
SN - 1873-9601
JO - Journal of Cell Communication and Signaling
JF - Journal of Cell Communication and Signaling
ER -