A network map of Interleukin-10 signaling pathway

Renu Verma, Lavanya Balakrishnan, Kusum Sharma, Aafaque Ahmad Khan, Jayshree Advani, Harsha Gowda, Srikanth Prasad Tripathy, Mrutyunjay Suar, Akhilesh Pandey, Sheetal Gandotra, T. S Keshava Prasad, Subramanian Shankar

Research output: Contribution to journalArticle

Abstract

Interleukin-10 (IL-10) is an anti-inflammatory cytokine with important immunoregulatory functions. It is primarily secreted by antigen-presenting cells such as activated T-cells, monocytes, B-cells and macrophages. In biologically functional form, it exists as a homodimer that binds to tetrameric heterodimer IL-10 receptor and induces downstream signaling. IL-10 is associated with survival, proliferation and anti-apoptotic activities of various cancers such as Burkitt lymphoma, non-Hodgkins lymphoma and non-small scell lung cancer. In addition, it plays a central role in survival and persistence of intracellular pathogens such as Leishmania donovani, Mycobacterium tuberculosis and Trypanosoma cruzi inside the host. The signaling mechanisms of IL-10 cytokine are not well explored and a well annotated pathway map has been lacking. To this end, we developed a pathway resource by manually annotating the IL-10 induced signaling molecules derived from literature. The reactions were categorized under molecular associations, activation/inhibition, catalysis, transport and gene regulation. In all, 37 molecules and 76 reactions were annotated. The IL-10 signaling pathway can be freely accessed through NetPath, a resource of signal transduction pathways previously developed by our group.

Original languageEnglish (US)
JournalJournal of Cell Communication and Signaling
DOIs
StateAccepted/In press - Aug 8 2015

Keywords

  • Co-stimulatory molecules
  • Interferon-gamma (IFN-γ)
  • Lipopolysaccharides
  • NetSlim
  • Pro-inflammatory cytokines
  • Protein-protein interactions
  • Systems biology markup language
  • Translocation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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  • Cite this

    Verma, R., Balakrishnan, L., Sharma, K., Khan, A. A., Advani, J., Gowda, H., Tripathy, S. P., Suar, M., Pandey, A., Gandotra, S., Prasad, T. S. K., & Shankar, S. (Accepted/In press). A network map of Interleukin-10 signaling pathway. Journal of Cell Communication and Signaling. https://doi.org/10.1007/s12079-015-0302-x