A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination

Seulki Lee; Eui Joon Cha; Kyeongsoon Park; Seung Young Lee; Jin Ki Hong; In Cheol Sun; Sang Yoon Kim; Kuiwon Choi; Ick Chan Kwon; Kwangmeyung Kim; Cheol Hee Ahn

doi:10.1002/anie.200705240

A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination

Seulki Lee, Eui Joon Cha, Kyeongsoon Park, Seung Young Lee, Jin Ki Hong, In Cheol Sun, Sang Yoon Kim, Kuiwon Choi, Ick Chan Kwon, Kwangmeyung Kim, Cheol Hee Ahn

Research output: Contribution to journal › Article › peer-review

271 Scopus citations

Abstract

(Figure Presented) Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected - both in vitro and in vivo. Experiments disclose an apparent positive contrast in MMPs-positive tumor-bearing mice (right).

Original language	English (US)
Pages (from-to)	2804-2807
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	15
DOIs	https://doi.org/10.1002/anie.200705240
State	Published - Mar 31 2008
Externally published	Yes

Keywords

Cancer diagnosis
Drug screening
Fluorescent probes
Gold
Imaging agents

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200705240

Cite this

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title = "A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination",

abstract = "(Figure Presented) Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected - both in vitro and in vivo. Experiments disclose an apparent positive contrast in MMPs-positive tumor-bearing mice (right).",

keywords = "Cancer diagnosis, Drug screening, Fluorescent probes, Gold, Imaging agents",

author = "Seulki Lee and Cha, {Eui Joon} and Kyeongsoon Park and Lee, {Seung Young} and Hong, {Jin Ki} and Sun, {In Cheol} and Kim, {Sang Yoon} and Kuiwon Choi and Kwon, {Ick Chan} and Kwangmeyung Kim and Ahn, {Cheol Hee}",

year = "2008",

month = mar,

day = "31",

doi = "10.1002/anie.200705240",

language = "English (US)",

volume = "47",

pages = "2804--2807",

journal = "Angewandte Chemie - International Edition",

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publisher = "John Wiley and Sons Ltd",

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T1 - A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination

AU - Lee, Seulki

AU - Cha, Eui Joon

AU - Park, Kyeongsoon

AU - Lee, Seung Young

AU - Hong, Jin Ki

AU - Sun, In Cheol

AU - Kim, Sang Yoon

AU - Choi, Kuiwon

AU - Kwon, Ick Chan

AU - Kim, Kwangmeyung

AU - Ahn, Cheol Hee

PY - 2008/3/31

Y1 - 2008/3/31

N2 - (Figure Presented) Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected - both in vitro and in vivo. Experiments disclose an apparent positive contrast in MMPs-positive tumor-bearing mice (right).

AB - (Figure Presented) Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected - both in vitro and in vivo. Experiments disclose an apparent positive contrast in MMPs-positive tumor-bearing mice (right).

KW - Cancer diagnosis

KW - Drug screening

KW - Fluorescent probes

KW - Gold

KW - Imaging agents

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DO - 10.1002/anie.200705240

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination

Abstract

Keywords

ASJC Scopus subject areas

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