A near-infrared fluorescence-based optical thermosensor

Seung Young Lee, Seulki Lee, In Chan Youn, Dong Kee Yi, Yong Taik Lim, Bong Hyun Chung, James F. Leary, Ick Chan Kwon, Kwangmeyung Kim, Kuiwon Choi

Research output: Contribution to journalArticle

Abstract

A study was conducted to demonstrate the development of a fluorescent polymeric thermosensor, exhibiting selective near-infrared (NIR) emission throughout a broad range of temperatures based on the fluorescent signal activation method. The NIR fluorescent thermosensor had the advantage to be applied in biological and medical field, as it was possible to image tissues at different resolutions and depth penetrations in minimizing tissue autofluorescence in NIR region. The thermosensor was designed using a combination of thermo-responsive polymer and an NIR dye, Pluronic F127, and Cy5.5. It was demonstrated that it was possible to synthesize a thermosensor for monitoring specific temperature range by using proper block copolymers. It was also demonstrated that the sensitive quenching properties of polymeric sensors allowed to monitor temperature changes by observing changes in NIR emission intensity and by visualized fluorescent images.

Original languageEnglish (US)
Pages (from-to)6103-6106
Number of pages4
JournalChemistry - A European Journal
Volume15
Issue number25
DOIs
StatePublished - Jun 15 2009
Externally publishedYes

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Fluorescence
Infrared radiation
UCON 50-HB-5100
Tissue
Poloxamer
Temperature
Block copolymers
Quenching
Polymers
Coloring Agents
Dyes
Chemical activation
Monitoring
Sensors

Keywords

  • Aggregation
  • Imaging agents
  • Micelles
  • Sensors

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Lee, S. Y., Lee, S., Youn, I. C., Yi, D. K., Lim, Y. T., Chung, B. H., ... Choi, K. (2009). A near-infrared fluorescence-based optical thermosensor. Chemistry - A European Journal, 15(25), 6103-6106. https://doi.org/10.1002/chem.200900683

A near-infrared fluorescence-based optical thermosensor. / Lee, Seung Young; Lee, Seulki; Youn, In Chan; Yi, Dong Kee; Lim, Yong Taik; Chung, Bong Hyun; Leary, James F.; Kwon, Ick Chan; Kim, Kwangmeyung; Choi, Kuiwon.

In: Chemistry - A European Journal, Vol. 15, No. 25, 15.06.2009, p. 6103-6106.

Research output: Contribution to journalArticle

Lee, SY, Lee, S, Youn, IC, Yi, DK, Lim, YT, Chung, BH, Leary, JF, Kwon, IC, Kim, K & Choi, K 2009, 'A near-infrared fluorescence-based optical thermosensor', Chemistry - A European Journal, vol. 15, no. 25, pp. 6103-6106. https://doi.org/10.1002/chem.200900683
Lee, Seung Young ; Lee, Seulki ; Youn, In Chan ; Yi, Dong Kee ; Lim, Yong Taik ; Chung, Bong Hyun ; Leary, James F. ; Kwon, Ick Chan ; Kim, Kwangmeyung ; Choi, Kuiwon. / A near-infrared fluorescence-based optical thermosensor. In: Chemistry - A European Journal. 2009 ; Vol. 15, No. 25. pp. 6103-6106.
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