Abstract
Objective Absolute risk and risk factors for recurrence and ovarian serous carcinoma following ovarian serous borderline tumors (SBTs) is not well-established. Methods We included all women with SBTs in Denmark, 1978–2002. Diagnoses were confirmed by centralized pathology review and classified as atypical proliferative serous tumor (APST) or noninvasive low-grade serous carcinoma (LGSC). Implants were classified as noninvasive or invasive. Medical records were collected and reviewed, and follow-up was obtained. Subsequent diagnoses were also confirmed by centralized pathology review. We examined absolute risk and risk factors for recurrent APST and serous carcinoma using Cox regression. Results The absolute serous carcinoma risk after, respectively, 5 and 20 years was 5.0% and 13.9% for noninvasive LGSC, and 0.9% and 3.7% for APST. Serous carcinoma risk was significantly higher following noninvasive LGSC compared with APST among stage I patients/patients without implants (HR = 5.3; 95% CI: 1.7–16.3), whereas no significant association with tumor type was found in advanced stage patients/patients with implants. Advanced stage – notably invasive implants – bilaterality, surface involvement, and residual disease increased serous carcinoma risk. However, women with stage I APST also had a higher risk than the general population. Conclusions This largest population-based cohort of verified SBTs revealed that women with noninvasive LGSC are significantly more likely to develop serous carcinoma than women with APST, which could not entirely be explained by invasive implants. Although invasive implants was a strong risk factor for serous carcinoma, even women with stage I APST were at increased risk compared with the general population.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 174-180 |
| Number of pages | 7 |
| Journal | Gynecologic Oncology |
| Volume | 144 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2017 |
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Keywords
- Atypical proliferative serous tumor (APST)
- Centralized pathology review
- Long-term follow-up
- Noninvasive low-grade serous carcinoma (LGSC)
- Ovarian serous borderline tumor (SBT)
- Population-based
- Risk of development of ovarian serous carcinoma
- Risk of recurrent APST
ASJC Scopus subject areas
- Oncology
- Obstetrics and Gynecology
Cite this
A nationwide study of ovarian serous borderline tumors in Denmark 1978–2002. Risk of recurrence, and development of ovarian serous carcinoma. / Hannibal, Charlotte Gerd; Vang, Russell; Junge, Jette; Frederiksen, Kirsten; Kurman, Robert J.; Kjaer, Susanne K.
In: Gynecologic Oncology, Vol. 144, No. 1, 01.01.2017, p. 174-180.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A nationwide study of ovarian serous borderline tumors in Denmark 1978–2002. Risk of recurrence, and development of ovarian serous carcinoma
AU - Hannibal,Charlotte Gerd
AU - Vang,Russell
AU - Junge,Jette
AU - Frederiksen,Kirsten
AU - Kurman,Robert J.
AU - Kjaer,Susanne K.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objective Absolute risk and risk factors for recurrence and ovarian serous carcinoma following ovarian serous borderline tumors (SBTs) is not well-established. Methods We included all women with SBTs in Denmark, 1978–2002. Diagnoses were confirmed by centralized pathology review and classified as atypical proliferative serous tumor (APST) or noninvasive low-grade serous carcinoma (LGSC). Implants were classified as noninvasive or invasive. Medical records were collected and reviewed, and follow-up was obtained. Subsequent diagnoses were also confirmed by centralized pathology review. We examined absolute risk and risk factors for recurrent APST and serous carcinoma using Cox regression. Results The absolute serous carcinoma risk after, respectively, 5 and 20 years was 5.0% and 13.9% for noninvasive LGSC, and 0.9% and 3.7% for APST. Serous carcinoma risk was significantly higher following noninvasive LGSC compared with APST among stage I patients/patients without implants (HR = 5.3; 95% CI: 1.7–16.3), whereas no significant association with tumor type was found in advanced stage patients/patients with implants. Advanced stage – notably invasive implants – bilaterality, surface involvement, and residual disease increased serous carcinoma risk. However, women with stage I APST also had a higher risk than the general population. Conclusions This largest population-based cohort of verified SBTs revealed that women with noninvasive LGSC are significantly more likely to develop serous carcinoma than women with APST, which could not entirely be explained by invasive implants. Although invasive implants was a strong risk factor for serous carcinoma, even women with stage I APST were at increased risk compared with the general population.
AB - Objective Absolute risk and risk factors for recurrence and ovarian serous carcinoma following ovarian serous borderline tumors (SBTs) is not well-established. Methods We included all women with SBTs in Denmark, 1978–2002. Diagnoses were confirmed by centralized pathology review and classified as atypical proliferative serous tumor (APST) or noninvasive low-grade serous carcinoma (LGSC). Implants were classified as noninvasive or invasive. Medical records were collected and reviewed, and follow-up was obtained. Subsequent diagnoses were also confirmed by centralized pathology review. We examined absolute risk and risk factors for recurrent APST and serous carcinoma using Cox regression. Results The absolute serous carcinoma risk after, respectively, 5 and 20 years was 5.0% and 13.9% for noninvasive LGSC, and 0.9% and 3.7% for APST. Serous carcinoma risk was significantly higher following noninvasive LGSC compared with APST among stage I patients/patients without implants (HR = 5.3; 95% CI: 1.7–16.3), whereas no significant association with tumor type was found in advanced stage patients/patients with implants. Advanced stage – notably invasive implants – bilaterality, surface involvement, and residual disease increased serous carcinoma risk. However, women with stage I APST also had a higher risk than the general population. Conclusions This largest population-based cohort of verified SBTs revealed that women with noninvasive LGSC are significantly more likely to develop serous carcinoma than women with APST, which could not entirely be explained by invasive implants. Although invasive implants was a strong risk factor for serous carcinoma, even women with stage I APST were at increased risk compared with the general population.
KW - Atypical proliferative serous tumor (APST)
KW - Centralized pathology review
KW - Long-term follow-up
KW - Noninvasive low-grade serous carcinoma (LGSC)
KW - Ovarian serous borderline tumor (SBT)
KW - Population-based
KW - Risk of development of ovarian serous carcinoma
KW - Risk of recurrent APST
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U2 - 10.1016/j.ygyno.2016.11.007
DO - 10.1016/j.ygyno.2016.11.007
M3 - Article
VL - 144
SP - 174
EP - 180
JO - Gynecologic Oncology
T2 - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 1
ER -