A nasal critical-size defect: An experimental model for the evaluation of facial osseous repair techniques

William H. Lindsey, David A. Franz, James S. Toung, Scott London, Roy O. Ogle

Research output: Contribution to journalArticle

Abstract

Objective: To create a standardized nonhealing defect of craniofacial, minimal load-bearing, endochondral type bone with geometric properties that are amenable to quantitative and biomechanical testing that can be used to develop new osteoconductive and osteoinductive engineering repair techniques. Design: Before-and-after randomized trial of an anatomical description. Subjects: Twenty-four retired male breeder Sprague-Dawley rats. Methods: A standardized osseous defect was created by removing the nasal bones with a cutting burr to the level of the nasal mucosal membranes. The defects were not repaired, and groups of 8 animals were examined using planimetry, computed tomographic scanning, and histological analysis at 1, 3, and 6 months following surgery to quantify defect repair. Results: Mean repair rate by surface area measurements at 1, 3, and 6 months was 5.75%, 4.89%, and 7.09%, respectively. Results from histological analysis revealed that the defects were filled with fibrous tissue. Computed tomographic scans showed the bone defect without repair. Conclusion: This nasal osseous defect fulfills criteria to be considered as a critical-size defect that can be used to investigate new techniques for bone reconstruction.

Original languageEnglish (US)
Pages (from-to)912-915
Number of pages4
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume124
Issue number8
StatePublished - Aug 1998
Externally publishedYes

Fingerprint

Nose
Theoretical Models
Bone and Bones
Nasal Bone
Weight-Bearing
Sprague Dawley Rats
Membranes

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

A nasal critical-size defect : An experimental model for the evaluation of facial osseous repair techniques. / Lindsey, William H.; Franz, David A.; Toung, James S.; London, Scott; Ogle, Roy O.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 124, No. 8, 08.1998, p. 912-915.

Research output: Contribution to journalArticle

Lindsey, William H. ; Franz, David A. ; Toung, James S. ; London, Scott ; Ogle, Roy O. / A nasal critical-size defect : An experimental model for the evaluation of facial osseous repair techniques. In: Archives of Otolaryngology - Head and Neck Surgery. 1998 ; Vol. 124, No. 8. pp. 912-915.
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