A Mutation in the β3-Adrenergic Receptor Gene Is Associated with Obesity and Hyperinsulinemia in Japanese Subjects

Hiroko Kadowaki, kazuki Yasuda, Keishi Iwamoto, Shuichi Otabe, Kotaro Shimokawa, Kristi Silver, Jeremy Walston, Hideo Yoshinaga, Kinori Kosaka, Nobuhiro Yamada, Yasushi Saito, Ryoko Hagura, Yasuo Akanuma, Alan Shuldiner, Yoshio Yazaki, Takashi Kadowaki

Research output: Contribution to journalArticle

Abstract

The Trp 64 Arg mutation in the β3-adrenergic receptor (β3AR) gene was investigated in 350 Japanese subjects. This mutation was not associated with non-insulin-dependent diabetes mellitus (NIDDM). In 191 subjects without NIDDM, body mass index (BMI) was significantly higher in subjects homozygous for this mutation than in those homozygous for the normal allele (24.7±1.4 vs 22.1±0.2 kg/m2, p=0.009). Moreover, the frequency of the mutant allele in obese subjects (BMI 26.4) was significantly higher than that in non-obese subjects (BMI<22) (0.37 vs 0.15, p=0.009). The presence of this mutation was also accompanied by significantly higher fasting (p=0.000) and 2 hrs (p=0.018) serum insulin levels during an oral glucose tolerance test. The β3AR may be one of the loci contributing to obesity and hyperinsulinemia/insulin resistance in Japanese subjects.

Original languageEnglish (US)
Pages (from-to)555-560
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume215
Issue number2
DOIs
StatePublished - Jan 1 1995

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Kadowaki, H., Yasuda, K., Iwamoto, K., Otabe, S., Shimokawa, K., Silver, K., Walston, J., Yoshinaga, H., Kosaka, K., Yamada, N., Saito, Y., Hagura, R., Akanuma, Y., Shuldiner, A., Yazaki, Y., & Kadowaki, T. (1995). A Mutation in the β3-Adrenergic Receptor Gene Is Associated with Obesity and Hyperinsulinemia in Japanese Subjects. Biochemical and Biophysical Research Communications, 215(2), 555-560. https://doi.org/10.1006/bbrc.1995.2500