TY - JOUR
T1 - A Multidimensional Prognostic Index (MPI) based on a comprehensive geriatric assessment predicts short- and long-term all-cause mortality in older hospitalized patients with transient ischemic attack
AU - Sancarlo, Daniele
AU - Pilotto, Andrea
AU - Panza, Francesco
AU - Copetti, Massimiliano
AU - Longo, Maria Grazia
AU - D'Ambrosio, Piero
AU - D'Onofrio, Grazia
AU - Ferrucci, Luigi
AU - Pilotto, Alberto
PY - 2012/4
Y1 - 2012/4
N2 - A multidimensional impairment may influence the clinical outcome of acute diseases in older patients. The aim of the current study was to evaluate whether a Multidimensional Prognostic Index (MPI) based on a comprehensive geriatric assessment (CGA) predicts short- and longterm all-cause mortality in older patients hospitalized for transient ischemic attack (TIA). In this prospective study with 1-year follow-up, 654 patients aged 65 and older with a diagnosis of TIA according to the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM 435.x) were enrolled. A standardized CGA that included information on functional (activities of daily living, ADL, and Instrumental ADL), cognitive status (Short Portable Mental Status Questionnaire), nutrition (Mini Nutritional Assessment), risk of pressure sores (Exton-Smith Scale), comorbidities (Cumulative Illness Rating Scale), medications and co-habitation status was used to calculate the MPI for mortality using a previously validated algorithm. Higher MPI values were significantly associated with higher 1-month all-cause mortality (incidence rates: MPI-1 low risk = 0.32%, MPI-2 moderate risk = 5.36%, MPI-3 high risk = 10.42%; p
AB - A multidimensional impairment may influence the clinical outcome of acute diseases in older patients. The aim of the current study was to evaluate whether a Multidimensional Prognostic Index (MPI) based on a comprehensive geriatric assessment (CGA) predicts short- and longterm all-cause mortality in older patients hospitalized for transient ischemic attack (TIA). In this prospective study with 1-year follow-up, 654 patients aged 65 and older with a diagnosis of TIA according to the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM 435.x) were enrolled. A standardized CGA that included information on functional (activities of daily living, ADL, and Instrumental ADL), cognitive status (Short Portable Mental Status Questionnaire), nutrition (Mini Nutritional Assessment), risk of pressure sores (Exton-Smith Scale), comorbidities (Cumulative Illness Rating Scale), medications and co-habitation status was used to calculate the MPI for mortality using a previously validated algorithm. Higher MPI values were significantly associated with higher 1-month all-cause mortality (incidence rates: MPI-1 low risk = 0.32%, MPI-2 moderate risk = 5.36%, MPI-3 high risk = 10.42%; p
KW - Aging
KW - All-cause mortality
KW - Comprehensive geriatric assessment (CGA)
KW - Multidimensional prognostic index (MPI)
KW - Risk factor
KW - Transient ischemic attack (TIA)
UR - http://www.scopus.com/inward/record.url?scp=84862519537&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862519537&partnerID=8YFLogxK
U2 - 10.1007/s00415-011-6241-4
DO - 10.1007/s00415-011-6241-4
M3 - Article
C2 - 21947223
AN - SCOPUS:84862519537
SN - 0340-5354
VL - 259
SP - 670
EP - 678
JO - Journal of Neurology
JF - Journal of Neurology
IS - 4
ER -