A Multidimensional Prognostic Index (MPI) based on a comprehensive geriatric assessment predicts short- and long-term all-cause mortality in older hospitalized patients with transient ischemic attack

Daniele Sancarlo, Andrea Pilotto, Francesco Panza, Massimiliano Copetti, Maria Grazia Longo, Piero D'Ambrosio, Grazia D'Onofrio, Luigi Ferrucci, Alberto Pilotto

Research output: Contribution to journalArticle

Abstract

A multidimensional impairment may influence the clinical outcome of acute diseases in older patients. The aim of the current study was to evaluate whether a Multidimensional Prognostic Index (MPI) based on a comprehensive geriatric assessment (CGA) predicts short- and longterm all-cause mortality in older patients hospitalized for transient ischemic attack (TIA). In this prospective study with 1-year follow-up, 654 patients aged 65 and older with a diagnosis of TIA according to the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM 435.x) were enrolled. A standardized CGA that included information on functional (activities of daily living, ADL, and Instrumental ADL), cognitive status (Short Portable Mental Status Questionnaire), nutrition (Mini Nutritional Assessment), risk of pressure sores (Exton-Smith Scale), comorbidities (Cumulative Illness Rating Scale), medications and co-habitation status was used to calculate the MPI for mortality using a previously validated algorithm. Higher MPI values were significantly associated with higher 1-month all-cause mortality (incidence rates: MPI-1 low risk = 0.32%, MPI-2 moderate risk = 5.36%, MPI-3 high risk = 10.42%; p

Original languageEnglish (US)
Pages (from-to)670-678
Number of pages9
JournalJournal of Neurology
Volume259
Issue number4
DOIs
StatePublished - Apr 2012
Externally publishedYes

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Keywords

  • Aging
  • All-cause mortality
  • Comprehensive geriatric assessment (CGA)
  • Multidimensional prognostic index (MPI)
  • Risk factor
  • Transient ischemic attack (TIA)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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