A multicentre, prospective, randomized, controlled trial comparing EVARREST™ fibrin sealant patch to standard of care in controlling bleeding following elective hepatectomy: anatomic versus non-anatomic resection

Jonathan B. Koea, Jonathan Batiller, Nicolas Aguirre, Jessica Shen, Richard Kocharian, Grant Bochicchio, O. James Garden

Research output: Contribution to journalArticlepeer-review

Abstract

Background This multicentre, randomized clinical trial assessed the safety and effectiveness of the EVARREST™ Fibrin Sealant Patch (FP) in treating parenchymal bleeding following anatomic and non-anatomic liver resections. Methods One hundred and two patients were stratified according to the type of hepatic resection (anatomic/non-anatomic), and randomized (1:1) after identification of an appropriate bleeding site, to FP vs Standard of Care (SoC, manual compression ± topical haemostat). The primary endpoint was haemostasis at 4 min from bleeding site identification with no re-bleeding requiring re-treatment. Results The FP was superior in achieving haemostasis at 4 min (96%, 48/50) to SoC (46%, 24/52; p 

Original languageEnglish (US)
Pages (from-to)221-228
Number of pages8
JournalHPB
Volume18
Issue number3
DOIs
StatePublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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