A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia

Ned Sacktor; Richard L. Skolasky; Thomas Ernst; Xiangling Mao; Ola Selnes; Martin G. Pomper; Linda Chang; Kai Zhong; Dikoma C. Shungu; Karen Marder; Dean Shibata; Giovanni Schifitto; Linda Bobo; Peter B. Barker; D. Phil

doi:10.1002/jmri.20272

A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia

Ned Sacktor, Richard L. Skolasky, Thomas Ernst, Xiangling Mao, Ola Selnes, Martin G. Pomper, Linda Chang, Kai Zhong, Dikoma C. Shungu, Karen Marder, Dean Shibata, Giovanni Schifitto, Linda Bobo, Peter B. Barker, D. Phil

School of Medicine

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Purpose: To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia. Materials and Methods: Twenty HIV-positive (HIV+) individuals underwent SV-MRS (TE 35 msec) and MRSI (TE 280 msec). Results were stratified according to serostatus, dementia severity, psychomotor speed performance, and functional impairment. Results: HIV+ individuals with psychomotor slowing had an increased myoinositol/creatine (mI/Cr) ratio (0.63 vs. 0.45) in the frontal white matter using SV-MRS and an increased choline (Cho)/Cr ratio (1.88 vs. 1.41) in the mesial frontal gray matter using MRSI compared to HIV+ individuals without psychomotor slowing. Using MRSI, subjects with HIV dementia also had a decreased N-acetyl aspartate (NAA)/Cho ratio (1.55 vs. 2.53) compared to HIV+ individuals without cognitive impairment in the mesial frontal gray matter. Both techniques detected metabolite ratio abnormalities associated with abnormal functional performance. Conclusion: SV-MRS and MRSI offer complementary roles in evaluating individuals with HIV dementia. Short TE SV-MRS measures ml, which may be elevated in early HIV dementia, whereas MRSI provides wider spatial coverage to examine specific regional changes.

Original language	English (US)
Pages (from-to)	325-333
Number of pages	9
Journal	Journal of Magnetic Resonance Imaging
Volume	21
Issue number	4
DOIs	https://doi.org/10.1002/jmri.20272
State	Published - Apr 2005

Keywords

Dementia
HIV
Magnetic resonance spectroscopy
Multicenter
Technique

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/jmri.20272

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Sacktor, N., Skolasky, R. L., Ernst, T., Mao, X., Selnes, O., Pomper, M. G., Chang, L., Zhong, K., Shungu, D. C., Marder, K., Shibata, D., Schifitto, G., Bobo, L., Barker, P. B., & Phil, D. (2005). A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia. Journal of Magnetic Resonance Imaging, 21(4), 325-333. https://doi.org/10.1002/jmri.20272

Sacktor, N, Skolasky, RL, Ernst, T, Mao, X, Selnes, O, Pomper, MG, Chang, L, Zhong, K, Shungu, DC, Marder, K, Shibata, D, Schifitto, G, Bobo, L, Barker, PB & Phil, D 2005, 'A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia', Journal of Magnetic Resonance Imaging, vol. 21, no. 4, pp. 325-333. https://doi.org/10.1002/jmri.20272

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abstract = "Purpose: To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia. Materials and Methods: Twenty HIV-positive (HIV+) individuals underwent SV-MRS (TE 35 msec) and MRSI (TE 280 msec). Results were stratified according to serostatus, dementia severity, psychomotor speed performance, and functional impairment. Results: HIV+ individuals with psychomotor slowing had an increased myoinositol/creatine (mI/Cr) ratio (0.63 vs. 0.45) in the frontal white matter using SV-MRS and an increased choline (Cho)/Cr ratio (1.88 vs. 1.41) in the mesial frontal gray matter using MRSI compared to HIV+ individuals without psychomotor slowing. Using MRSI, subjects with HIV dementia also had a decreased N-acetyl aspartate (NAA)/Cho ratio (1.55 vs. 2.53) compared to HIV+ individuals without cognitive impairment in the mesial frontal gray matter. Both techniques detected metabolite ratio abnormalities associated with abnormal functional performance. Conclusion: SV-MRS and MRSI offer complementary roles in evaluating individuals with HIV dementia. Short TE SV-MRS measures ml, which may be elevated in early HIV dementia, whereas MRSI provides wider spatial coverage to examine specific regional changes.",

keywords = "Dementia, HIV, Magnetic resonance spectroscopy, Multicenter, Technique",

author = "Ned Sacktor and Skolasky, {Richard L.} and Thomas Ernst and Xiangling Mao and Ola Selnes and Pomper, {Martin G.} and Linda Chang and Kai Zhong and Shungu, {Dikoma C.} and Karen Marder and Dean Shibata and Giovanni Schifitto and Linda Bobo and Barker, {Peter B.} and D. Phil",

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doi = "10.1002/jmri.20272",

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AU - Sacktor, Ned

AU - Skolasky, Richard L.

AU - Ernst, Thomas

AU - Mao, Xiangling

AU - Selnes, Ola

AU - Pomper, Martin G.

AU - Chang, Linda

AU - Zhong, Kai

AU - Shungu, Dikoma C.

AU - Marder, Karen

AU - Shibata, Dean

AU - Schifitto, Giovanni

AU - Bobo, Linda

AU - Barker, Peter B.

AU - Phil, D.

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N2 - Purpose: To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia. Materials and Methods: Twenty HIV-positive (HIV+) individuals underwent SV-MRS (TE 35 msec) and MRSI (TE 280 msec). Results were stratified according to serostatus, dementia severity, psychomotor speed performance, and functional impairment. Results: HIV+ individuals with psychomotor slowing had an increased myoinositol/creatine (mI/Cr) ratio (0.63 vs. 0.45) in the frontal white matter using SV-MRS and an increased choline (Cho)/Cr ratio (1.88 vs. 1.41) in the mesial frontal gray matter using MRSI compared to HIV+ individuals without psychomotor slowing. Using MRSI, subjects with HIV dementia also had a decreased N-acetyl aspartate (NAA)/Cho ratio (1.55 vs. 2.53) compared to HIV+ individuals without cognitive impairment in the mesial frontal gray matter. Both techniques detected metabolite ratio abnormalities associated with abnormal functional performance. Conclusion: SV-MRS and MRSI offer complementary roles in evaluating individuals with HIV dementia. Short TE SV-MRS measures ml, which may be elevated in early HIV dementia, whereas MRSI provides wider spatial coverage to examine specific regional changes.

AB - Purpose: To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia. Materials and Methods: Twenty HIV-positive (HIV+) individuals underwent SV-MRS (TE 35 msec) and MRSI (TE 280 msec). Results were stratified according to serostatus, dementia severity, psychomotor speed performance, and functional impairment. Results: HIV+ individuals with psychomotor slowing had an increased myoinositol/creatine (mI/Cr) ratio (0.63 vs. 0.45) in the frontal white matter using SV-MRS and an increased choline (Cho)/Cr ratio (1.88 vs. 1.41) in the mesial frontal gray matter using MRSI compared to HIV+ individuals without psychomotor slowing. Using MRSI, subjects with HIV dementia also had a decreased N-acetyl aspartate (NAA)/Cho ratio (1.55 vs. 2.53) compared to HIV+ individuals without cognitive impairment in the mesial frontal gray matter. Both techniques detected metabolite ratio abnormalities associated with abnormal functional performance. Conclusion: SV-MRS and MRSI offer complementary roles in evaluating individuals with HIV dementia. Short TE SV-MRS measures ml, which may be elevated in early HIV dementia, whereas MRSI provides wider spatial coverage to examine specific regional changes.

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KW - HIV

KW - Magnetic resonance spectroscopy

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A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia

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