TY - JOUR
T1 - A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission
AU - Schleicher, Tyler R.
AU - Yang, Jing
AU - Freudzon, Marianna
AU - Rembisz, Alison
AU - Craft, Samuel
AU - Hamilton, Madeleine
AU - Graham, Morven
AU - Mlambo, Godfree
AU - Tripathi, Abhai K.
AU - Li, Yue
AU - Cresswell, Peter
AU - Sinnis, Photini
AU - Dimopoulos, George
AU - Fikrig, Erol
N1 - Publisher Copyright:
© 2018, The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - The key step during the initiation of malaria is for motile Plasmodium parasites to exit the host dermis and infect the liver. During transmission, the parasites in the form of sporozoites, are injected together with mosquito saliva into the skin. However, the contribution of vector saliva to sporozoite activity during the establishment of the initial infection of the liver is poorly understood. Here we identify a vector protein by mass spectrometry, with similarity to the human gamma interferon inducible thiol reductase (GILT), that is associated with saliva sporozoites of infected Anopheles mosquitoes and has a negative impact on the speed and cell traversal activity of Plasmodium. This protein, referred to as mosquito GILT (mosGILT) represents an example of a protein found in mosquito saliva that may negatively influence sporozoite movement in the host and could lead to new approaches to prevent malaria.
AB - The key step during the initiation of malaria is for motile Plasmodium parasites to exit the host dermis and infect the liver. During transmission, the parasites in the form of sporozoites, are injected together with mosquito saliva into the skin. However, the contribution of vector saliva to sporozoite activity during the establishment of the initial infection of the liver is poorly understood. Here we identify a vector protein by mass spectrometry, with similarity to the human gamma interferon inducible thiol reductase (GILT), that is associated with saliva sporozoites of infected Anopheles mosquitoes and has a negative impact on the speed and cell traversal activity of Plasmodium. This protein, referred to as mosquito GILT (mosGILT) represents an example of a protein found in mosquito saliva that may negatively influence sporozoite movement in the host and could lead to new approaches to prevent malaria.
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U2 - 10.1038/s41467-018-05374-3
DO - 10.1038/s41467-018-05374-3
M3 - Article
C2 - 30046053
AN - SCOPUS:85050699641
SN - 2041-1723
VL - 9
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 2908
ER -