A morphometric study of arterial intimal thickening in kidneys of dialyzed patients

T. Nishi, C. Bond, G. Brown, K. Solez, R. H. Heptinstall

Research output: Contribution to journalArticlepeer-review

Abstract

Arterial intimal thickening is common in the end-stage kidneys of patients maintained on hemodialysis. The authors measured the intimal thickening in patients dialyzed for varying periods and in patients with the malignant phase of essential hypertension and with scleroderma-associated renal failure. The ratio of intimal area to medial area in intrarenal arteries was used as a measure of intimal thickening. In the dialysis groups, intimal thickening was relatively constant in arteries of all sizes and correlated with duration of dialysis, particularly in larger arteries. In the malignant hypertension and scleroderma groups, the intimal thickening was greatest in arteries less than 200 μ in diameter and least in those over 500 μ in diameter. There was much less intimal thickening in arteries of all sizes in kidneys of patients with a similar diastolic blood pressure and similar duration of dialysis. It is believed that the intimal thickening in dialyzed patients is probably a disuse type of change and may be related to reduction in the area of the renal microvascular bed.

Original languageEnglish (US)
Pages (from-to)597-610
Number of pages14
JournalAmerican Journal of Pathology
Volume95
Issue number3
StatePublished - Oct 15 1979

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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