TY - JOUR
T1 - A morphometric assessment of type I Chiari malformation above the McRae line
T2 - A retrospective case-control study in 302 adult female subjects
AU - Houston, James R.
AU - Eppelheimer, Maggie S.
AU - Pahlavian, Soroush Heidari
AU - Biswas, Dipankar
AU - Urbizu, Aintzane
AU - Martin, Bryn A.
AU - Bapuraj, Jayapalli Rajiv
AU - Luciano, Mark
AU - Allen, Philip A.
AU - Loth, Francis
N1 - Publisher Copyright:
© 2017
PY - 2018/2
Y1 - 2018/2
N2 - Purpose: Type I Chiari malformation (CMI) is a radiologically-defined structural dysmorphism of the hindbrain and posterior cranial fossa (PCF). Traditional radiographic identification of CMI relies on the measurement of the cerebellar tonsils in relation to the foramen magnum with or without associated abnormalities of the neuraxis. The primary goal of this retrospective study was to comprehensively assess morphometric parameters above the McRea line in a group of female CMI patients and normal controls. Material and methods: Twenty-nine morphological measurements were taken on 302 mid-sagittal MR images of adult female CMI patients (n = 162) and healthy controls (n = 140). All MR images were voluntarily provided by CMI subjects through an online database and control participant images were obtained through the Human Connectome Project and a local hospital system. Results: Analyses were performed on the full dataset of adult female MR images and a restricted dataset of 229 participants that were equated for age, race, and body mass index. Eighteen group differences were identified in the PCF area that we grouped into three clusters; PCF structures heights, clivus angulation, and odontoid process irregularity. Fourteen group differences persisted after equating our CMI and control groups on demographic characteristics. Conclusion: PCF structures reliably differ in adult female CMI patients relative to healthy controls. These differences reflect structural abnormalities in the osseous and soft tissue structures of the clivus, odontoid process, and cerebellum. Clinical and pathophysiological implications are discussed.
AB - Purpose: Type I Chiari malformation (CMI) is a radiologically-defined structural dysmorphism of the hindbrain and posterior cranial fossa (PCF). Traditional radiographic identification of CMI relies on the measurement of the cerebellar tonsils in relation to the foramen magnum with or without associated abnormalities of the neuraxis. The primary goal of this retrospective study was to comprehensively assess morphometric parameters above the McRea line in a group of female CMI patients and normal controls. Material and methods: Twenty-nine morphological measurements were taken on 302 mid-sagittal MR images of adult female CMI patients (n = 162) and healthy controls (n = 140). All MR images were voluntarily provided by CMI subjects through an online database and control participant images were obtained through the Human Connectome Project and a local hospital system. Results: Analyses were performed on the full dataset of adult female MR images and a restricted dataset of 229 participants that were equated for age, race, and body mass index. Eighteen group differences were identified in the PCF area that we grouped into three clusters; PCF structures heights, clivus angulation, and odontoid process irregularity. Fourteen group differences persisted after equating our CMI and control groups on demographic characteristics. Conclusion: PCF structures reliably differ in adult female CMI patients relative to healthy controls. These differences reflect structural abnormalities in the osseous and soft tissue structures of the clivus, odontoid process, and cerebellum. Clinical and pathophysiological implications are discussed.
KW - Chiari I malformation
KW - Cranio-vertebral junction
KW - MRI
KW - Morphometry
KW - Odontoid
KW - Posterior cranial fossa
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U2 - 10.1016/j.neurad.2017.06.006
DO - 10.1016/j.neurad.2017.06.006
M3 - Article
C2 - 28826656
AN - SCOPUS:85027585030
SN - 0150-9861
VL - 45
SP - 23
EP - 31
JO - Journal of Neuroradiology
JF - Journal of Neuroradiology
IS - 1
ER -