TY - JOUR
T1 - A morphometric analysis of neuroanatomic abnormalities in traumatic brain injury
AU - Vannorsdall, Tracy D.
AU - Cascella, Nicola G.
AU - Vani, Rao
AU - Pearlson, Godfrey D.
AU - Gordon, Barry
AU - Schretlen, David J.
PY - 2010
Y1 - 2010
N2 - Cognitive and structural brain abnormalities are common following traumatic brain injury (TBI). The authors compared cognition and brain structure in 14 TBI survivors and 28 matched healthy comparison subjects. TBI survivors showed reduced cerebral volume, due mainly to white matter changes, and poorer attention, psychomotor speed, and memory. Severity of white matter abnormality correlated with worse performance on several cognitive measures that distinguished between groups. Using voxel-based morphometry, regions of reduced white matter concentration were found throughout the cerebrum along with more localized gray matter reductions. Findings suggest that diffuse rather than focal aspects of TBI contribute most to cognitive outcome.
AB - Cognitive and structural brain abnormalities are common following traumatic brain injury (TBI). The authors compared cognition and brain structure in 14 TBI survivors and 28 matched healthy comparison subjects. TBI survivors showed reduced cerebral volume, due mainly to white matter changes, and poorer attention, psychomotor speed, and memory. Severity of white matter abnormality correlated with worse performance on several cognitive measures that distinguished between groups. Using voxel-based morphometry, regions of reduced white matter concentration were found throughout the cerebrum along with more localized gray matter reductions. Findings suggest that diffuse rather than focal aspects of TBI contribute most to cognitive outcome.
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U2 - 10.1176/jnp.2010.22.2.173
DO - 10.1176/jnp.2010.22.2.173
M3 - Article
C2 - 20463111
AN - SCOPUS:77952365802
SN - 0895-0172
VL - 22
SP - 173
EP - 181
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 2
ER -