A morphometric analysis of neuroanatomic abnormalities in traumatic brain injury

Tracy D. Vannorsdall, Nicola G. Cascella, Rao Vani, Godfrey D. Pearlson, Barry Gordon, David J. Schretlen

Research output: Contribution to journalArticle

Abstract

Cognitive and structural brain abnormalities are common following traumatic brain injury (TBI). The authors compared cognition and brain structure in 14 TBI survivors and 28 matched healthy comparison subjects. TBI survivors showed reduced cerebral volume, due mainly to white matter changes, and poorer attention, psychomotor speed, and memory. Severity of white matter abnormality correlated with worse performance on several cognitive measures that distinguished between groups. Using voxel-based morphometry, regions of reduced white matter concentration were found throughout the cerebrum along with more localized gray matter reductions. Findings suggest that diffuse rather than focal aspects of TBI contribute most to cognitive outcome.

Original languageEnglish (US)
Pages (from-to)173-181
Number of pages9
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume22
Issue number2
DOIs
StatePublished - Jan 1 2010

    Fingerprint

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this