A morphological study of penile chancroid lesions in human immunodeficiency virus (HIV)-positive and -negative African men with a hypothesis concerning the role of chancroid in HIV transmission

C. M. Magro, A. N. Crowson, M. Alfa, A. Nath, A. Ronald, J. O. Ndinya-Achola, J. Nasio

Research output: Contribution to journalArticle

Abstract

Chancroid, the most common cause of genital ulceration in Africa, is known to be associated epidemiologically with heterosexual transmission of human immunodeficiency virus (HIV). The pathophysiological mechanisms by which chancroid might facilitate the spread of HIV are obscure. To investigate the role of chancroid in HIV transmission, the authors studied the histological features of biopsies from 11 men with positive for HIV. The histomorphologic and immunophenotypic nature of the inflammatory infiltrates suggests that there is a significant role for cell-mediated immunity in the host response to Hemophilus ducreyi infection. This response may be critical to the role of cancroid in HIV transmission.

Original languageEnglish (US)
Pages (from-to)1066-1070
Number of pages5
JournalHuman pathology
Volume27
Issue number10
DOIs
StatePublished - 1996

Keywords

  • HIV transmission
  • cell-mediated immunity
  • chancroid
  • genital ulcer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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