A monoclonal antibody detecting a possible public specificity of the HLA‐C locus

Corazon L. Dejelo; William E. Braun; Andrea A. Zachary; Alan Smerglia; Linda Clark

doi:10.1111/j.1399-0039.1986.tb00461.x

A monoclonal antibody detecting a possible public specificity of the HLA‐C locus

Corazon L. Dejelo, William E. Braun, Andrea A. Zachary, Alan Smerglia, Linda Clark

Research output: Contribution to journal › Article › peer-review

Abstract

An IgM monoclonal antibody (CC‐C1 11) was produced by fusing myeloma cell line SP2/08 with lymphocytes of a Balb/c mouse previously immunized with peripheral blood lymphocytes of an A2, Bw44, B27, Cw1, Cw7, DR5 donor. Reactivity of CC‐C1 11 on a lymphocyte panel of 172 unrelated donors and lysostripping and absorption experiments have shown that CC‐C1 11 recognizes an antigenic determinant common to HLA‐Cw1 and Cw3 positive lymphocytes.

Original language	English (US)
Pages (from-to)	57-62
Number of pages	6
Journal	Tissue Antigens
Volume	28
Issue number	1
DOIs	https://doi.org/10.1111/j.1399-0039.1986.tb00461.x
State	Published - Jul 1986
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Genetics

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10.1111/j.1399-0039.1986.tb00461.x

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abstract = "An IgM monoclonal antibody (CC‐C1 11) was produced by fusing myeloma cell line SP2/08 with lymphocytes of a Balb/c mouse previously immunized with peripheral blood lymphocytes of an A2, Bw44, B27, Cw1, Cw7, DR5 donor. Reactivity of CC‐C1 11 on a lymphocyte panel of 172 unrelated donors and lysostripping and absorption experiments have shown that CC‐C1 11 recognizes an antigenic determinant common to HLA‐Cw1 and Cw3 positive lymphocytes.",

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year = "1986",

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AU - Dejelo, Corazon L.

AU - Braun, William E.

AU - Zachary, Andrea A.

AU - Smerglia, Alan

AU - Clark, Linda

PY - 1986/7

Y1 - 1986/7

N2 - An IgM monoclonal antibody (CC‐C1 11) was produced by fusing myeloma cell line SP2/08 with lymphocytes of a Balb/c mouse previously immunized with peripheral blood lymphocytes of an A2, Bw44, B27, Cw1, Cw7, DR5 donor. Reactivity of CC‐C1 11 on a lymphocyte panel of 172 unrelated donors and lysostripping and absorption experiments have shown that CC‐C1 11 recognizes an antigenic determinant common to HLA‐Cw1 and Cw3 positive lymphocytes.

AB - An IgM monoclonal antibody (CC‐C1 11) was produced by fusing myeloma cell line SP2/08 with lymphocytes of a Balb/c mouse previously immunized with peripheral blood lymphocytes of an A2, Bw44, B27, Cw1, Cw7, DR5 donor. Reactivity of CC‐C1 11 on a lymphocyte panel of 172 unrelated donors and lysostripping and absorption experiments have shown that CC‐C1 11 recognizes an antigenic determinant common to HLA‐Cw1 and Cw3 positive lymphocytes.

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A monoclonal antibody detecting a possible public specificity of the HLA‐C locus

Abstract

ASJC Scopus subject areas

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