A monoclonal antibody detecting a possible public specificity of the HLA‐C locus

Corazon L. Dejelo, William E. Braun, Andrea A. Zachary, Alan Smerglia, Linda Clark

Research output: Contribution to journalArticlepeer-review

Abstract

An IgM monoclonal antibody (CC‐C1 11) was produced by fusing myeloma cell line SP2/08 with lymphocytes of a Balb/c mouse previously immunized with peripheral blood lymphocytes of an A2, Bw44, B27, Cw1, Cw7, DR5 donor. Reactivity of CC‐C1 11 on a lymphocyte panel of 172 unrelated donors and lysostripping and absorption experiments have shown that CC‐C1 11 recognizes an antigenic determinant common to HLA‐Cw1 and Cw3 positive lymphocytes.

Original languageEnglish (US)
Pages (from-to)57-62
Number of pages6
JournalTissue Antigens
Volume28
Issue number1
DOIs
StatePublished - Jul 1986

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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